(Q90678056)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30573184%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects (English)

1 reference

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15 April 2020

5

Martin Hauer-Jensen

1 reference

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15 April 2020

author name string

Nukhet Aykin-Burns

1

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15 April 2020

Rupak Pathak

2

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15 April 2020

Marjan Boerma

3

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15 April 2020

Thomas Kim

4

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15 April 2020

publication date

1 January 2019

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Seminars in Radiation Oncology

15 April 2020

published in

1 reference

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15 April 2020

volume

29

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15 April 2020

issue

1

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15 April 2020

page(s)

55-61

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Effect of pentoxifylline on energy rich phosphates in rat's erythrocytes

15 April 2020

cites work

1 reference

12 December 2020

Studies on the biological activity of tocotrienols

1 reference

12 December 2020

Vitamin E: interactions with free radicals and ascorbate

1 reference

12 December 2020

The cooperative antioxidant role of glutathione with a lipid-soluble and a water-soluble antioxidant during peroxidation of liposomes initiated in the aqueous phase and in the lipid phase

1 reference

12 December 2020

Inhibition of peroxidation of membranes.

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12 December 2020

Antioxidants in relation to lipid peroxidation

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12 December 2020

Effect of phytyl side chain of vitamin E on its antioxidant activity

1 reference

12 December 2020

Effect of pentoxifylline on cerebral edema in cats.

1 reference

12 December 2020

The influence of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (pentoxifylline, BL 191) on serum calcium and magnesium levels

1 reference

12 December 2020

Interaction between an organic hydroperoxide and an unsaturated phospholipid and alpha-tocopherol in model membranes

1 reference

12 December 2020

Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

12 December 2020

Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency

1 reference

12 December 2020

Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: observations in humans and hamsters.

1 reference

12 December 2020

Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria

1 reference

12 December 2020

Nitrofurantoin-induced hepatic and pulmonary biochemical changes in mice fed different vitamin E doses

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12 December 2020

Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes

1 reference

12 December 2020

Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?

1 reference

12 December 2020

Radiation-induced normal tissue injury: role of adhesion molecules in leukocyte-endothelial cell interactions

1 reference

12 December 2020

Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR)

1 reference

12 December 2020

Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status

1 reference

12 December 2020

Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis

1 reference

12 December 2020

Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family

1 reference

12 December 2020

The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.

1 reference

12 December 2020

Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion

1 reference

12 December 2020

The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein

1 reference

12 December 2020

Development of gamma (gamma)-tocopherol as a colorectal cancer chemopreventive agent

1 reference

12 December 2020

Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency

1 reference

12 December 2020

New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine

1 reference

12 December 2020

Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation

1 reference

12 December 2020

Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations

1 reference

12 December 2020

Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.

1 reference

12 December 2020

Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules

1 reference

12 December 2020

The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism

1 reference

12 December 2020

Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis

1 reference

12 December 2020

Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone

1 reference

12 December 2020

Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.

1 reference

12 December 2020

Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols

1 reference

12 December 2020

Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal.

1 reference

12 December 2020

Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of alpha-tocopherol

1 reference

12 December 2020

Role of Krüppel-like transcription factors in endothelial biology

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12 December 2020

ON THE EXISTENCE OF A HITHERTO UNRECOGNIZED DIETARY FACTOR ESSENTIAL FOR REPRODUCTION.

1 reference

12 December 2020

Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells

1 reference

12 December 2020

Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin

1 reference

12 December 2020

Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol

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12 December 2020

Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol).

1 reference

12 December 2020

Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits

1 reference

12 December 2020

Studies on pentoxifylline and tocopherol combination for radiation-induced heart disease in rats

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12 December 2020

Suppression of tumor growth by palm tocotrienols via the attenuation of angiogenesis

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12 December 2020

Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector

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12 December 2020

gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism

1 reference

12 December 2020

delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not.

1 reference

12 December 2020

Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats

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12 December 2020

Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation

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12 December 2020

Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling

1 reference

12 December 2020

Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.

1 reference

12 December 2020

Effects of vitamin E on receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in rats treated with nicotine

1 reference

12 December 2020

Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems

1 reference

12 December 2020

Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform δ-Tocotrienol

1 reference

12 December 2020

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

1 reference

12 December 2020

Palm tocotrienols decrease levels of pro-angiogenic markers in human umbilical vein endothelial cells (HUVEC) and murine mammary cancer cells

1 reference

12 December 2020

eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

1 reference

12 December 2020

γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways.

1 reference

12 December 2020

γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death

1 reference

12 December 2020

Tocotrienol as a potential anticancer agent

1 reference

12 December 2020

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

1 reference

12 December 2020

Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure

1 reference

12 December 2020

Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures

1 reference

12 December 2020

Potential role of tocotrienols in the treatment and prevention of breast cancer

1 reference

12 December 2020

Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival

1 reference

12 December 2020

Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury

1 reference

12 December 2020

Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor

1 reference

12 December 2020

Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability

1 reference

12 December 2020

Clinical Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain White Matter

1 reference

12 December 2020

Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model.

1 reference

12 December 2020

Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in mice

1 reference

12 December 2020

Oxazine derivatives of γ- and δ-tocotrienol display enhanced anticancer activity in vivo.

1 reference

12 December 2020

Synergistic radioprotection by gamma-tocotrienol and pentoxifylline: role of cAMP signaling

1 reference

12 December 2020

δ-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxia

1 reference

12 December 2020

Hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia

1 reference

12 December 2020

Tocotrienol-rich fraction (TRF) suppresses the growth of human colon cancer xenografts in Balb/C nude mice by the Wnt pathway

1 reference

12 December 2020

Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ cells from radiation injury

1 reference

12 December 2020

Hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1α/CXCR4 pathway in non-small cell lung carcinoma cells

1 reference

12 December 2020

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice

1 reference

12 December 2020

Antiproliferative effects of γ-tocotrienol are associated with lipid raft disruption in HER2-positive human breast cancer cells

1 reference

12 December 2020

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway

1 reference

12 December 2020

A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

1 reference

12 December 2020

Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates

1 reference

12 December 2020

Tocotrienol and cancer metastasis

1 reference

12 December 2020

Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen

1 reference

12 December 2020

Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells.

1 reference

12 December 2020

The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage

1 reference

12 December 2020

Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites

1 reference

12 December 2020

γ-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is associated with inhibition of canonical Wnt signalling

1 reference

12 December 2020

Delta- and gamma-tocotrienol isomers are potent in inhibiting inflammation and endothelial activation in stimulated human endothelial cells

1 reference

12 December 2020

Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model

1 reference

12 December 2020

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules

1 reference

12 December 2020

δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.

1 reference

12 December 2020

Biological Properties of Tocotrienols: Evidence in Human Studies

1 reference

12 December 2020

Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin

1 reference

12 December 2020

The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM).

1 reference

12 December 2020

A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27.

1 reference

12 December 2020

Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion

1 reference

12 December 2020

A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells

1 reference

12 December 2020

Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol

1 reference

12 December 2020

Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection

1 reference

12 December 2020

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

1 reference

12 December 2020

Synthesis, characterization, and in-vitro antitumor activity of the polyethylene glycol (350 and 1000) succinate derivatives of the tocopherol and tocotrienol isomers of Vitamin E.

1 reference

12 December 2020

Synergistic Impact of d-δ-Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells

1 reference

12 December 2020

δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis

1 reference

12 December 2020

Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment.

1 reference

12 December 2020

Repurposing Pentoxifylline for the Treatment of Fibrosis: An Overview.

1 reference

12 December 2020

Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A.

1 reference

12 December 2020

Gemcitabine-vitamin E conjugates: Synthesis, characterization, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity

1 reference

12 December 2020

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.

1 reference

12 December 2020

γ-Tocotrienol Inhibits Proliferation and Induces Apoptosis Via the Mitochondrial Pathway in Human Cervical Cancer HeLa Cells

1 reference

12 December 2020

Tumor regression and modulation of gene expression via tumor-targeted tocotrienol niosomes.

1 reference

12 December 2020

Natural Forms of Vitamin E as Effective Agents for Cancer Prevention and Therapy.

1 reference

12 December 2020

Development and in-vitro characterization of nanoemulsions loaded with paclitaxel/γ-tocotrienol lipid conjugates.

1 reference

12 December 2020

Combination Effect of δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth

1 reference

12 December 2020

A Metabolomic and Lipidomic Serum Signature from Nonhuman Primates Administered with a Promising Radiation Countermeasure, Gamma-Tocotrienol.

1 reference

12 December 2020

Targeting melanoma stem cells with the Vitamin E derivative δ-tocotrienol.

1 reference

12 December 2020

Vitamin E Phosphate Nucleoside Prodrugs: A Platform for Intracellular Delivery of Monophosphorylated Nucleosides.

1 reference

12 December 2020

Suppressive Effect of Delta-Tocotrienol on Hypoxia Adaptation of Prostate Cancer Stem-like Cells.

1 reference

12 December 2020

Tocotrienols: The promising analogues of vitamin E for cancer therapeutics.

1 reference

12 December 2020

Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury.

1 reference

12 December 2020

10.1016/J.SEMRADONC.2018.10.008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30573184%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30573184%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PubMed publication ID

30573184

1 reference