(Q92984481)

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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease

scientific article published on 08 November 2018

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scholarly article

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2 May 2020

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease (English)

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2 May 2020

Alzheimer's disease

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Alexandra Litvinchuk

1

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2 May 2020

Ying-Wooi Wan

2

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2 May 2020

Dan B Swartzlander

3

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2 May 2020

Fading Chen

4

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2 May 2020

Allysa Cole

5

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2 May 2020

Nicholas E Propson

6

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2 May 2020

Qian Wang

7

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2 May 2020

Bin Zhang

8

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2 May 2020

Zhandong Liu

9

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2 May 2020

Hui Zheng

10

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publication date

8 November 2018

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2 May 2020

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2 May 2020

100

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2 May 2020

6

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2 May 2020

1337-1353.e5

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2 May 2020

describes a project that uses

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11 June 2022

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Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease

1 reference

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Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

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Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

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Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

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Neurotoxic reactive astrocytes are induced by activated microglia

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A complement-microglial axis drives synapse loss during virus-induced memory impairment

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The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?

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11 February 2021

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

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Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.

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11 February 2021

Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.

1 reference

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11 February 2021

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

1 reference

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11 February 2021

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.

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11 February 2021

Neuroinflammation in Alzheimer's disease

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11 February 2021

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

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Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

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11 February 2021

NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

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An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons

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Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

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Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau

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Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

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Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

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The complement system: an unexpected role in synaptic pruning during development and disease

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11 February 2021

Identifiers

10.1016/J.NEURON.2018.10.031

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2 May 2020

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2 May 2020

1 reference

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2 May 2020

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