(Q93012758)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

title

WRN helicase is a synthetic lethal target in microsatellite unstable cancers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Raymond W S Ng

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Aviad Tsherniak

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Francisca Vazquez

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

38

Todd R Golub

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

34

David E Root

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

35

Jesse S Boehm

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

author name string

Edmond M Chan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Tsukasa Shibue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

James M McFarland

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Benjamin Gaeta

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Nancy Dumont

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Alfredo Gonzalez

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Justine S McPartlan

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Tianxia Li

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Yanxi Zhang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Jie Bin Liu

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Jean-Bernard Lazaro

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Peili Gu

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Cortt G Piett

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Annie Apffel

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Syed O Ali

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Rebecca Deasy

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Paula Keskula

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Emma A Roberts

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Elizaveta Reznichenko

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Lisa Leung

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Maria Alimova

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Monica Schenone

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Mirazul Islam

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Yosef E Maruvka

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Yang Liu

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Jatin Roper

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Srivatsan Raghavan

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Marios Giannakis

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Yuen-Yi Tseng

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Zachary D Nagel

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Alan D'Andrea

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Gad Getz

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Sandy Chang

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Adam J Bass

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

language of work or name

English

0 references

publication date

10 April 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

volume

568

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

issue

7753

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

page(s)

551-556

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

3 May 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/6580861

inferred from PubMed Central ID database lookup

cites work

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

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Mutational processes shape the landscape of TP53 mutations in human cancer.

11 February 2021

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Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer.

11 February 2021

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Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6580861

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

11 February 2021

1 reference

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New use of microsatellite instability analysis in endometrial cancer

11 February 2021

1 reference

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

11 February 2021

1 reference

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Defining a Cancer Dependency Map.

11 February 2021

1 reference

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The 'Pushmi-Pullyu' of DNA REPAIR: Clinical Synthetic Lethality

11 February 2021

1 reference

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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

11 February 2021

1 reference

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A landscape of pharmacogenomic interactions in cancer.

11 February 2021

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PARP inhibitors: the race is on.

11 February 2021

1 reference

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The Molecular Signatures Database (MSigDB) hallmark gene set collection

11 February 2021

1 reference

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Pharmacogenomic agreement between two cancer cell line data sets.

11 February 2021

1 reference

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Mismatch repair during homologous and homeologous recombination

11 February 2021

1 reference

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limma powers differential expression analyses for RNA-sequencing and microarray studies

11 February 2021

1 reference

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Organoid models of human and mouse ductal pancreatic cancer

11 February 2021

1 reference

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Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing

11 February 2021

1 reference

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Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

11 February 2021

1 reference

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Comprehensive molecular characterization of gastric adenocarcinoma

11 February 2021

1 reference

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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

11 February 2021

1 reference

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Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

11 February 2021

1 reference

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voom: Precision weights unlock linear model analysis tools for RNA-seq read counts

11 February 2021

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The landscape of microsatellite instability in colorectal and endometrial cancer genomes

11 February 2021

1 reference

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Targeting an Achilles' heel of cancer with a WRN helicase inhibitor

11 February 2021

1 reference

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

11 February 2021

1 reference

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C911: A bench-level control for sequence specific siRNA off-target effects

11 February 2021

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The intersection between DNA damage response and cell death pathways

11 February 2021

1 reference

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The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions

11 February 2021

1 reference

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

11 February 2021

1 reference

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Harnessing synthetic lethal interactions in anticancer drug discovery

11 February 2021

1 reference

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A scaling normalization method for differential expression analysis of RNA-seq data

11 February 2021

1 reference

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Roles of Werner syndrome protein in protection of genome integrity

11 February 2021

1 reference

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

11 February 2021

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DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.

11 February 2021

1 reference

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The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation

11 February 2021

1 reference

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Systematic review and meta-analysis of ovarian cancers: estimation of microsatellite-high frequency and characterization of mismatch repair deficient tumor histology

11 February 2021

1 reference

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Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

11 February 2021

1 reference

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Roles of the Werner syndrome RecQ helicase in DNA replication

11 February 2021

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6580861

The Werner syndrome protein has separable recombination and survival functions

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6580861

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6580861

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

11 February 2021

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1102-X

7 January 2021

Whole-exome sequencing for finding de novo mutations in sporadic mental retardation

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1102-X

7 January 2021

Least-Squares Means: The R Package lsmeans

1 reference

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7 January 2021

Fitting Linear Mixed-Effects Models Using lme4

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1102-X

7 January 2021

10.1038/S41586-019-1102-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30971823%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

1 reference