(Q93186435)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

review article

1 reference

title

Macrophage Rewiring by Nutrient Associated PI3K Dependent Pathways (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Julia Brunner

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

author name string

Andrea Vogel

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Gernot Schabbauer

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

publication date

21 August 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

published in

Frontiers in Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

page(s)

2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

4 May 2020

copyright license

start time

21 August 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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A lipase-independent pathway of lipid release and immune modulation by adipocytes

11 February 2021

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MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism

11 February 2021

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Exosomes: biogenesis, biologic function and clinical potential

11 February 2021

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Immunometabolism at the interface between macrophages and pathogens

11 February 2021

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Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

11 February 2021

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Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

11 February 2021

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Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

11 February 2021

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Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

11 February 2021

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Cross-talk between insulin signalling and LPS responses in mouse macrophages

11 February 2021

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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

11 February 2021

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Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems.

11 February 2021

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Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation

11 February 2021

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Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

11 February 2021

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The PI3K Pathway in Human Disease

11 February 2021

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PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity

11 February 2021

1 reference

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High glucose induces alternative activation of macrophages via PI3K/Akt signaling pathway

11 February 2021

1 reference

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Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization.

11 February 2021

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Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.

11 February 2021

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Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

11 February 2021

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A guide to immunometabolism for immunologists.

11 February 2021

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Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

11 February 2021

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Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

11 February 2021

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Palmitate differentially regulates the polarization of differentiating and differentiated macrophages

11 February 2021

1 reference

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Ceramides - Lipotoxic Inducers of Metabolic Disorders

11 February 2021

1 reference

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Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

11 February 2021

1 reference

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Concentration-Dependent Diversifcation Effects of Free Cholesterol Loading on Macrophage Viability and Polarization

11 February 2021

1 reference

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Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease

11 February 2021

1 reference

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The cell biology of fat expansion

11 February 2021

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The phosphoinositide 3-kinase signaling pathway is involved in the control of modified low-density lipoprotein uptake by human macrophages

11 February 2021

1 reference

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Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.

11 February 2021

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Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages

11 February 2021

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Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

11 February 2021

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Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses

11 February 2021

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The M1 and M2 paradigm of macrophage activation: time for reassessment

11 February 2021

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Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.

11 February 2021

1 reference

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Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.

11 February 2021

1 reference

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Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation

11 February 2021

1 reference

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Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation

11 February 2021

1 reference

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Adipose tissue macrophages: Amicus adipem?

11 February 2021

1 reference

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Akt1-mediated regulation of macrophage polarization in a murine model of Staphylococcus aureus pulmonary infection.

11 February 2021

1 reference

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Adipose tissue foam cells are present in human obesity

11 February 2021

1 reference

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Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages

11 February 2021

1 reference

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

11 February 2021

1 reference

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Regulation of glucose transport by insulin: traffic control of GLUT4.

11 February 2021

1 reference

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Macrophage-mediated inflammation in metabolic disease

11 February 2021

1 reference

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FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

11 February 2021

1 reference

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Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

11 February 2021

1 reference

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Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.

11 February 2021

1 reference

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Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance

11 February 2021

1 reference

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The PI3K pathway as drug target in human cancer

11 February 2021

1 reference

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Glucose metabolism is required for oxidized LDL-induced macrophage survival: role of PI3K and Bcl-2 family proteins.

11 February 2021

1 reference

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The Akt kinases: isoform specificity in metabolism and cancer

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals

11 February 2021

1 reference

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

11 February 2021

1 reference

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Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Metabolic endotoxemia initiates obesity and insulin resistance

11 February 2021

1 reference

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

11 February 2021

1 reference

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TLR4 links innate immunity and fatty acid-induced insulin resistance

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Critical nodes in signalling pathways: insights into insulin action

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

IKK-beta links inflammation to obesity-induced insulin resistance

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Increased CD36 protein as a response to defective insulin signaling in macrophages

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

The phosphoinositide 3-kinase pathway

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Insulin signalling and the regulation of glucose and lipid metabolism

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Distinct localization of GLUT-1, -3, and -5 in human monocyte-derived macrophages: effects of cell activation

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6712174

11 February 2021

Identifiers

DOI

10.3389/FIMMU.2019.02002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31497027%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

1 reference