(Q94948758)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

20 May 2020

title

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

20 May 2020

author name string

Valentina C Sladky

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

20 May 2020

Andreas Villunger

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

20 May 2020

publication date

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

20 May 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

Caspases in Cell Death, Inflammation, and Disease

20 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Cell-Cycle Cross Talk with Caspases and Their Substrates

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

New roles for old enzymes: killer caspases as the engine of cell behavior changes

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Human caspases: activation, specificity, and regulation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The PIDDosome, DNA-damage-induced apoptosis and beyond

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

RAIDD is a new 'death' adaptor molecule

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 activation in the absence of PIDDosome formation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

PIDD mediates NF-kappaB activation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

PIDD orchestrates translesion DNA synthesis in response to UV irradiation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 is required for cell death induced by cytoskeletal disruption

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 mediates neuronal cell death induced by beta-amyloid

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 at a glance

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The PIDDosome activates p53 in response to supernumerary centrosomes

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Defects in regulation of apoptosis in caspase-2-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

DNA damage- and stress-induced apoptosis occurs independently of PIDD

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 as a tumour suppressor

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2: an orphan enzyme out of the shadows

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

14-3-3 protein binding blocks the dimerization interface of caspase-2

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

14-3-3 protein masks the nuclear localization sequence of caspase-2

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 deficiency enhances aging-related traits in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

SREBPs: metabolic integrators in physiology and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Role of prodomain in importin-mediated nuclear localization and activation of caspase-2

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Physiological significance of polyploidization in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Liver tetraploidization is controlled by a new process of incomplete cytokinesis

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

E2F8 is essential for polyploidization in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Canonical and atypical E2Fs regulate the mammalian endocycle

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The Polyploid State Plays a Tumor-Suppressive Role in the Liver.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Tumors Following Chronic Liver Injury

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Osteoimmunology: interplay between the immune system and bone metabolism

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Once and only once: mechanisms of centriole duplication and their deregulation in disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 is required for skeletal muscle differentiation and myogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Myoblast fusion: lessons from flies and mice

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase 3 activity is required for skeletal muscle differentiation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

P21 deficiency delays regeneration of skeletal muscular tissue

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Mitochondrial pro-apoptotic indices do not precede the transient caspase activation associated with myogenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase selective reagents for diagnosing apoptotic mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2: the orphan caspase.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Centrosome proteins form an insoluble perinuclear matrix during muscle cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

A non-apoptotic role for caspase-9 in muscle differentiation

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Caspase-2 cleavage of tau reversibly impairs memory

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Homozygous null variant in CRADD, encoding an adaptor protein that mediates apoptosis, is associated with lissencephaly.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

RAIDD mutations underlie the pathogenesis of thin lissencephaly (TLIS)

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Genetic mapping and exome sequencing identify variants associated with five novel diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

The genetics of lissencephaly

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Phenotypic spectrum associated with a CRADD founder variant underlying frontotemporal predominant pachygyria in the Finnish population

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41418-020-0556-6

7 January 2021

10.1038/S41418-020-0556-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32415279%20AND%20SRC:MED&resulttype=core&format=json

20 May 2020

1 reference