(Q106518998)

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CDC42 GEFs activate CDC42

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9013159)

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9013159

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8 July 2022

CDC42:GDP [plasma membrane]

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CDC42:GTP [plasma membrane]

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8 July 2022

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

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8 July 2022

ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells

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8 July 2022

WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.

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8 July 2022

A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration

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8 July 2022

Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF.

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8 July 2022

Detection of Rho GEF and GAP activity through a sensitive split luciferase assay system

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8 July 2022

Asef is a Cdc42-specific guanine nucleotide exchange factor

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8 July 2022

Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

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8 July 2022

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8 July 2022

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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8 July 2022

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.

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8 July 2022

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42

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8 July 2022

Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth

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8 July 2022

Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor

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8 July 2022

Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells

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8 July 2022

Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.

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8 July 2022

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

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8 July 2022

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

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8 July 2022

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

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8 July 2022

LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis

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8 July 2022

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

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8 July 2022

DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells

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8 July 2022

Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

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8 July 2022

Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.

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8 July 2022

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

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8 July 2022

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

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8 July 2022

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

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8 July 2022

FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles

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8 July 2022

Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G Protein

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8 July 2022

Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1.

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8 July 2022

Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A.

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8 July 2022

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

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8 July 2022

Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites

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8 July 2022

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation

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8 July 2022

Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation

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8 July 2022

Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.

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8 July 2022

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells

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8 July 2022

Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors

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8 July 2022

Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes

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8 July 2022

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

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8 July 2022

DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.

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8 July 2022

Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

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8 July 2022

Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells

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8 July 2022

PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front

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8 July 2022

Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases

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8 July 2022

Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element

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8 July 2022

Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42

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8 July 2022

The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration

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8 July 2022

Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member

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8 July 2022

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

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8 July 2022

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

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8 July 2022

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

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8 July 2022

SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

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8 July 2022

p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.

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8 July 2022

A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.

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8 July 2022

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

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8 July 2022

A role for Rac in Tiam1-induced membrane ruffling and invasion

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8 July 2022

Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering.

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8 July 2022

Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

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8 July 2022

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

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8 July 2022

Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture

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8 July 2022

GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor

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8 July 2022

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

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8 July 2022

Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor

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8 July 2022

A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain

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8 July 2022

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

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8 July 2022

Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules

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8 July 2022

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

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8 July 2022

Scambio, a novel guanine nucleotide exchange factor for Rho

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8 July 2022

Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors

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8 July 2022

Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors

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8 July 2022

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

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8 July 2022

The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts

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8 July 2022

A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling

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8 July 2022

Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

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8 July 2022

The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.

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8 July 2022

The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.

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8 July 2022

Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.

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8 July 2022

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation

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8 July 2022

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

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8 July 2022

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

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8 July 2022

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

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8 July 2022

Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology.

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8 July 2022

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

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8 July 2022

Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

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8 July 2022

Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons

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8 July 2022

Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton

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8 July 2022

Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

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8 July 2022

Identifiers

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8 July 2022

(Q106518998)

CDC42 GEFs activate CDC42

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