(Q33289411)

25 July 2017

title

LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis (English)

1 reference

Leucine rich repeats and calponin homology domain containing 1

25 July 2017

main subject

1 reference

Dedicator of cytokinesis 8

1 reference

negative regulation of T cell migration

1 reference

Dedicator of cytokinesis 8

1 reference

Leucine-rich repeats and calponin homology (CH) domain containing 1

1 reference

experimental autoimmune encephalomyelitis

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Yunzhen Gao

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Peng Chen

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Bin Wei

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Hongyan Wang

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Xiaoyan Xu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Lei Han

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Guixian Zhao

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Jun Xiao

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Shicheng Zhang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Zhi-Ying Wu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Jianping Ding

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Ronggui Hu

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

27 December 2016

1 reference

Journal of Experimental Medicine

25 July 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

214

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

209-226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma

9 June 2020

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21 June 2018

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ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy

21 June 2018

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Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation

21 June 2018

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Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis

21 June 2018

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Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

21 June 2018

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Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair

21 June 2018

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

21 June 2018

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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

21 June 2018

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The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.

21 June 2018

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Integrin signalling and function in immune cells.

21 June 2018

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DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

21 June 2018

1 reference

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DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory

21 June 2018

1 reference

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

21 June 2018

1 reference

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Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1

21 June 2018

1 reference

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LRCH proteins: a novel family of cytoskeletal regulators

21 June 2018

1 reference

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Immunopathologies linked to integrin signalling

21 June 2018

1 reference

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Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

21 June 2018

1 reference

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Combined immunodeficiency associated with DOCK8 mutations

21 June 2018

1 reference

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SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

The ins and outs of leukocyte integrin signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Function of the N-terminus of zizimin1: autoinhibition and membrane targeting.

21 June 2018

1 reference

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Multiple sclerosis: a complicated picture of autoimmunity.

21 June 2018

1 reference

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Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion

21 June 2018

1 reference

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New therapeutic approaches for multiple sclerosis

21 June 2018

1 reference

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Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

21 June 2018

1 reference

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Analysis of activated GAPs and GEFs in cell lysates

21 June 2018

1 reference

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The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

21 June 2018

1 reference

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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

21 June 2018

1 reference

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An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Vav-family proteins in T-cell signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Cdc42--the centre of polarity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

21 June 2018

1 reference

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Three or more routes for leukocyte migration into the central nervous system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.

21 June 2018

1 reference

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Multiple pathways control protein kinase C phosphorylation

21 June 2018

1 reference

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

21 June 2018

1 reference

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Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5206493

Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population

21 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis--an intravital microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20160068

Distinct chemokine signaling regulates integrin ligand specificity to dictate tissue-specific lymphocyte homing

21 January 2018

1 reference

12 December 2020

Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus

1 reference

12 December 2020

The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment

1 reference

12 December 2020

Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20160068

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28028151%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference