(Q24298838)

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Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

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Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C (English)

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Receptor for activated C kinase 1

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GOA release 2020-03-11

molecular adaptor activity

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GOA release 2020-03-11

author name string

Rebecca J Bird

1

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George S Baillie

2

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Stephen J Yarwood

3

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language of work or name

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publication date

15 November 2010

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Biochemical Journal

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432

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1

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207-16

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copyright license

Creative Commons Attribution-NonCommercial 2.5 Generic

25 July 2019

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2973232/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

1 reference

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19 March 2017

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

19 March 2017

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1

1 reference

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19 March 2017

Keynote review: phosphodiesterase-4 as a therapeutic target

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19 March 2017

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

1 reference

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19 March 2017

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

1 reference

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19 March 2017

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

1 reference

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19 March 2017

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

19 March 2017

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture

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Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

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27 September 2017

EPAC proteins transduce diverse cellular actions of cAMP.

1 reference

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27 September 2017

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

1 reference

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27 September 2017

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

27 September 2017

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

1 reference

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27 September 2017

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

27 September 2017

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

1 reference

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27 September 2017

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

1 reference

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27 September 2017

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

1 reference

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27 September 2017

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

27 September 2017

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

27 September 2017

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2973232

27 September 2017

The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications

1 reference

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27 September 2017

Physiological substrates of cAMP-dependent protein kinase

1 reference

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27 September 2017

PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

1 reference

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27 September 2017

Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

1 reference

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27 September 2017

Synthesis and screening of peptide libraries on continuous cellulose membrane supports

1 reference

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27 September 2017

Effect of isoproterenol and aminophylline on cyclic AMP levels of guinea pig macrophages

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27 September 2017

Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.

1 reference

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30 May 2018

The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

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30 May 2018

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1 reference

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30 May 2018

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

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30 May 2018

Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101010

21 January 2018

Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).

1 reference

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29 November 2018

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