(Q24298838)

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Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

scientific article published on November 15, 2010

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Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C (English)

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Receptor for activated C kinase 1

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GOA release 2020-03-11

molecular adaptor activity

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GOA release 2020-03-11

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George S. Baillie

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

Stephen J. Yarwood

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Stephen J. Yarwood

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

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Rebecca J. Bird

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

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15 November 2010

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https://portlandpress.com/biochemj/article-pdf/432/1/207/665940/bj4320207.pdf

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20819076/pdf/?tool=EBI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20819076/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

https://europepmc.org/articles/PMC2973232

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

https://europepmc.org/articles/PMC2973232?pdf=render

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819076

7 July 2024

https://portlandpress.com/biochemj/article-pdf/432/1/207/665940/bj4320207.pdf

Portable Document Format

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10.1042/BJ20101010

https://api.crossref.org/works/10.1042/BJ20101010

7 July 2024

Biochemical Journal

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432

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1

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207-16

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Creative Commons Attribution-NonCommercial 2.5 Generic

25 July 2019

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2973232/fullTextXML

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Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

1 reference

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Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1 reference

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1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1

1 reference

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1 reference

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Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

1 reference

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1 reference

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19 March 2017

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

1 reference

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Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture

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Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

1 reference

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27 September 2017

EPAC proteins transduce diverse cellular actions of cAMP.

1 reference

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27 September 2017

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

1 reference

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27 September 2017

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

1 reference

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27 September 2017

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

1 reference

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27 September 2017

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

1 reference

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27 September 2017

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

1 reference

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27 September 2017

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

1 reference

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The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

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Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

1 reference

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

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The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

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Physiological substrates of cAMP-dependent protein kinase

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Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

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The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

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