(Q24305005)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

15 January 2020

main subject

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

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platelet aggregation

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author

Marie-Pierre Gratacap

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Julie Guillermet-Guibert

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Gaetan Chicanne

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

Fréderique Gaits-Iacovoni

15 January 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Valérie Martin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Hélène Tronchère

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Bernard Payrastre

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

language of work or name

English

0 references

publication date

28 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

Advances in Enzyme Regulation

15 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

106-116

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

Phosphoinositides and signal transduction

15 January 2020

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

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The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death

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PI 3-kinase p110beta: a new target for antithrombotic therapy

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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7 January 2021

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Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers

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Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.

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7 January 2021

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

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7 January 2021

Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways

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7 January 2021

Signalling through Class I PI3Ks in mammalian cells

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7 January 2021

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

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7 January 2021

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

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7 January 2021

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

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7 January 2021

A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

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7 January 2021

Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

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7 January 2021

Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol

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7 January 2021

The role of phosphoinositide 3-kinase lipid products in cell function

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7 January 2021

Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma

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7 January 2021

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7 January 2021

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

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7 January 2021

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7 January 2021

Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

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7 January 2021

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7 January 2021

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7 January 2021

Mutations in phosphoinositide metabolizing enzymes and human disease

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7 January 2021

PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer

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7 January 2021

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

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7 January 2021

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors

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7 January 2021

Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase

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7 January 2021

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7 January 2021

Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3

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7 January 2021

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation

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7 January 2021

The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation

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7 January 2021

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

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7 January 2021

Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

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7 January 2021

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference