(Q24310684)

1

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Christine Luong

2

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Joseph D Ho

3

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John R Somoza

4

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Erik Gjerstad

5

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Jie Tang

6

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Steven R Williams

7

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Erik Verner

8

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Wendy B Young

10

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Paul A Sprengeler

11

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Hedy Chan

12

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Kyle Mortara

13

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James W Janc

14

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Mary E McGrath

Journal of Molecular Biology

15

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language of work or name

English

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publication date

19 November 2004

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published in

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volume

344

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issue

2

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page(s)

527-47

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cites work

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Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases

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Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design

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Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

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An ester bond linking a fragment of a serine proteinase to its serpin inhibitor.

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Design, Synthesis, and Crystal Structure of Selective 2-Pyridone Tissue Factor VIIa Inhibitors

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Design of potent selective zinc-mediated serine protease inhibitors

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

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Structural basis for chemical inhibition of human blood coagulation factor Xa

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(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

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Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite

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Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system

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Crystal structure of the catalytic domain of human plasmin complexed with streptokinase

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Inhibitors of the protease domain of urokinase-type plasminogen activator

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