(Q24320103)

positive regulation of protein catabolic process

GOA release 2020-03-11

1 reference

Proceedings of the National Academy of Sciences of the United States of America

GOA release 2020-03-11

1 reference

0 references

Bernard L Schneider

2

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Hilal Lashuel

series ordinal

4

object named as

Hilal A Lashuel

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author name string

Abid Oueslati

series ordinal

1

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Patrick Aebischer

series ordinal

3

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language of work or name

English

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publication date

8 October 2013

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published in

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volume

110

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issue

41

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page(s)

E3945-54

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3799334/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

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Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication

19 March 2017

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Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain

19 March 2017

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Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

19 March 2017

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Polo-like kinase-2 is required for centriole duplication in mammalian cells

19 March 2017

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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

19 March 2017

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

19 March 2017

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Missing pieces in the Parkinson's disease puzzle

19 March 2017

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Protein degradation pathways in Parkinson's disease: curse or blessing

19 March 2017

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

19 March 2017

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Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory

19 March 2017

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

19 March 2017

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Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity

19 March 2017

1 reference

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Parkinson's disease. First of two parts

19 March 2017

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

7 April 2017

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α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2

27 September 2017

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Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

27 September 2017

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Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4).

27 September 2017

1 reference

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Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context

27 September 2017

1 reference

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Synaptic dysfunction in Parkinson's disease.

27 September 2017

1 reference

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Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

27 September 2017

1 reference

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α-synuclein phosphorylation and truncation are normal events in the adult human brain

27 September 2017

1 reference

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

27 September 2017

1 reference

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Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.

27 September 2017

1 reference

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Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Phosphorylation of synucleins by members of the Polo-like kinase family

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Neural plasticity in the ageing brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Polo-like kinases in the nervous system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Polo-like kinases (Plks) and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Regulation of cell cycle checkpoints by polo-like kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Polo-like kinases and oncogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

alpha-Synuclein is phosphorylated in synucleinopathy lesions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Parkinson's disease. Second of two parts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799334

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309991110

21 January 2018

Identifiers

DOI

10.1073/PNAS.1309991110

1 reference

ADS bibcode

2013PNAS..110E3945O

0 references

1 reference

1 reference

PubMed publication ID

23983262

1 reference