(Q24339194)

Regulator of calcineurin 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Min-Su Jung

1

0 references

Jung-Hwa Park

2

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Young Shin Ryu

3

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Sun-Hee Choi

4

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Song-Hee Yoon

5

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Mi-Yang Kwen

6

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Ji Youn Oh

7

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Woo-Joo Song

8

0 references

Sul-Hee Chung

Journal of Biological Chemistry

9

0 references

language of work or name

English

0 references

publication date

18 November 2011

0 references

published in

0 references

volume

286

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page(s)

40401-12

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issue

46

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3220559/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

19 March 2017

1 reference

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19 March 2017

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

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Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"

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Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21

19 March 2017

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Multiple domains of MCIP1 contribute to inhibition of calcineurin activity

19 March 2017

1 reference

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Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

19 March 2017

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

19 March 2017

1 reference

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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

19 March 2017

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

19 March 2017

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A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

19 March 2017

1 reference

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Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

19 March 2017

1 reference

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Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome

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MNB/DYRK1A as a multiple regulator of neuronal development

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Activation, regulation, and inhibition of DYRK1A.

27 September 2017

1 reference

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Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease

27 September 2017

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Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

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Function and regulation of Dyrk1A: towards understanding Down syndrome

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The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.

27 September 2017

1 reference

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Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast

27 September 2017

1 reference

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Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1.

27 September 2017

1 reference

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Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point

27 September 2017

1 reference

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NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

27 September 2017

1 reference

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DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

27 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

High-efficiency transfection of mammalian neurons via nucleofection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Cooperation to amplify gene-dosage-imbalance effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971

Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Reduction of calcineurin activity in brain by antisense oligonucleotides leads to persistent phosphorylation of tau protein at Thr181 and Thr231.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220559

Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21965663

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.253971