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3 March 2020

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26 August 2020

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein (English)

1 reference

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9 references

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31 July 2019

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cell surface receptor

1 reference

31 July 2019

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12 September 2019

biomedical investigative technique

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19 September 2019

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12 October 2019

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15 December 2019

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19 December 2019

Glutamate ionotropic receptor AMPA type subunit 4

1 reference

Glutamate ionotropic receptor NMDA type subunit 2B

1 reference

Glutamate ionotropic receptor NMDA type subunit 2A

1 reference

amyloid-beta binding

1 reference

1 reference

26 August 2020

Heledd Jarosz-Griffiths

1

1 reference

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3 March 2020

Nigel Mark Hooper

4

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3 March 2020

author name string

Elizabeth Noble

2

1 reference

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3 March 2020

Jo V Rushworth

3

1 reference

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3 March 2020

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30 December 2015

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Journal of Biological Chemistry

3 March 2020

12 February 2016

1 reference

26 August 2020

10

1 reference

based on heuristic

inferred from page(s)

published in

10 references

25 April 2019

31 July 2019

12 September 2019

19 September 2019

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19 December 2019

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26 August 2020

291

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issue

7

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3 March 2020

page(s)

3174-3183

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Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

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Clearance systems in the brain-implications for Alzheimer disease

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Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics

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Out-of-register -sheets suggest a pathway to toxic amyloid aggregates

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Atomic View of a Toxic Amyloid Small Oligomer

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits

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Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

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Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones

7 April 2017

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

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Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier

7 April 2017

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Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers

7 April 2017

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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

7 April 2017

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

7 April 2017

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Alzheimer's disease: the amyloid cascade hypothesis

7 April 2017

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A beta oligomers - a decade of discovery

7 April 2017

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Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

7 April 2017

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Neuronal clearance of amyloid-β by endocytic receptor LRP1.

9 May 2017

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LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

9 May 2017

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Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

9 May 2017

1 reference

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Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

9 May 2017

1 reference

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The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation

9 May 2017

1 reference

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Memory impairment in transgenic Alzheimer mice requires cellular prion protein

25 May 2017

1 reference

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Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

25 May 2017

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Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

28 September 2017

1 reference

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Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

28 September 2017

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Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

28 September 2017

1 reference

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Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity.

28 September 2017

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Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

28 September 2017

1 reference

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Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease

28 September 2017

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Toward a unified therapeutics approach targeting putative amyloid-β oligomer receptors

28 September 2017

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Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

28 September 2017

1 reference

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Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease

28 September 2017

1 reference

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Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis

28 September 2017

1 reference

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Fyn kinase inhibition as a novel therapy for Alzheimer's disease

28 September 2017

1 reference

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Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

28 September 2017

1 reference

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FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease

28 September 2017

1 reference

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A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Soluble aβ promotes wild-type tau pathology in vivo

28 September 2017

1 reference

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The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

28 September 2017

1 reference

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Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

28 September 2017

1 reference

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Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease.

28 September 2017

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Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

28 September 2017

1 reference

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Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

28 September 2017

1 reference

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

28 September 2017

1 reference

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Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology

28 September 2017

1 reference

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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

28 September 2017

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Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease.

28 September 2017

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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

28 September 2017

1 reference

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Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

28 September 2017

1 reference

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Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

28 September 2017

1 reference

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Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

28 September 2017

1 reference

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Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

28 September 2017

1 reference

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Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Structural classification of toxic amyloid oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Solution state characterization of amyloid beta-derived diffusible ligands

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Signalosomes in the brain: relevance in the development of certain neuropathologies such as Alzheimer's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751366

In situ Abeta pores in AD brain are cylindrical assembly of Abeta protofilaments.

31 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.702704

21 January 2018

Identifiers

DOI

10.1074/JBC.R115.702704

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26719327%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26719327%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

26719327

2 references