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The G protein α chaperone Ric-8 as a potential therapeutic target
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PubMed
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Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
review article
1 reference
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Europe PubMed Central
title
The G protein α chaperone Ric-8 as a potential therapeutic target
(English)
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
main subject
molecular chaperones
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author
Makaía M Papasergi-Scott
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
author name string
Bharti R Patel
series ordinal
2
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Europe PubMed Central
PMC publication ID
4279082
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
Gregory G Tall
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
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21 February 2020
language of work or name
English
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publication date
15 October 2014
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Europe PubMed Central
PMC publication ID
4279082
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
published in
Molecular Pharmacology
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
volume
87
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
issue
1
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
page(s)
52-63
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
cites work
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Crystal structure of the β2 adrenergic receptor-Gs protein complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Mutations in GNA11 in uveal melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
I-TASSER: a unified platform for automated protein structure and function prediction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Oncogenic mutations in GNAQ occur early in uveal melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
I-TASSER server for protein 3D structure prediction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Tcf4 can specifically recognize beta-catenin using alternative conformations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Functional analysis of Hsp70 inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Inhibition of oncogenic Wnt signaling through direct targeting of -catenin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Structural view of the Ran-Importin beta interaction at 2.3 A resolution
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Protein structure prediction on the Web: a case study using the Phyre server
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
The genomic landscapes of human breast and colorectal cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Targeting the dynamic HSP90 complex in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
NCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Structural basis for nuclear import complex dissociation by RanGTP
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
7 April 2017
Novel insights into G protein and G protein-coupled receptor signaling in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8 regulation of heterotrimeric G proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
HSP90 inhibitors: current development and potential in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
A modified HSP70 inhibitor shows broad activity as an anticancer agent
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
The guanine nucleotide exchange factor RIC8 regulates conidial germination through Gα proteins in Neurospora crassa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Hsp70 protein complexes as drug targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
G protein-coupled receptors as therapeutic targets for multiple sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Hsp90 molecular chaperone inhibitors: are we there yet?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Oncogene addiction in gliomas: implications for molecular targeted therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Importazole, a small molecule inhibitor of the transport receptor importin-β
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
G protein-coupled receptors: novel targets for drug discovery in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Armadillo-repeat protein functions: questions for little creatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Spindle orientation during asymmetric cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Myr-Ric-8A enhances G(alpha15)-mediated Ca2+ response of vertebrate olfactory receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Mechanisms of asymmetric stem cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Assembly and trafficking of heterotrimeric G proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Cardiac GPCRs: GPCR signaling in healthy and failing hearts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
G-protein-coupled receptors and cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8B promotes functional expression of odorant receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Antimyeloma activity of heat shock protein-90 inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8B, an olfactory putative GTP exchange factor, amplifies signal transduction through the olfactory-specific G-protein Galphaolf.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Oncogene addiction: sometimes a temporary slavery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Mutant G-protein-coupled receptors as a cause of human diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Heterotrimeric G proteins: new tricks for an old dog.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Evidence mounts for receptor-independent activation of heterotrimeric G proteins normally in vivo: positioning of the mitotic spindle in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Heterotrimeric G protein signaling: role in asthma and allergic inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
In vivo newly translated polypeptides are sequestered in a protected folding environment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Mss4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
A genetic selection for Caenorhabditis elegans synaptic transmission mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 September 2017
Ric-8A, a Galpha protein guanine nucleotide exchange factor potentiates taste receptor signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Biophysical studies support a predicted superhelical structure with armadillo repeats for Ric-8.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Molecular genetic analysis of two G alpha protein subunits in Dictyostelium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
31 May 2018
Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
xRic-8 is a GEF for Gsalpha and participates in maintaining meiotic arrest in Xenopus laevis oocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Drosophila G-protein signalling: intricate roles for Ric-8?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Assembly and intracellular targeting of the betagamma subunits of heterotrimeric G proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279082
retrieved
28 November 2018
Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25319541
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phase II study of deoxyspergualin in metastatic breast cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25319541
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
RIC-8 (Synembryn)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1124%2FMOL.114.094664
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Notch signalling by non-visual beta-arrestin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1124%2FMOL.114.094664
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HSP90 Inhibitors: Current Development and Potential in Cancer Therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1124%2FMOL.114.094664
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1124/MOL.114.094664
1 reference
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
PMC publication ID
4279082
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
PubMed publication ID
25319541
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMC publication ID
4279082
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319541%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 February 2020
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