(Q34752099)

4 August 2017

title

SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. (English)

1 reference

4 August 2017

1 reference

John Sondek

7

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author name string

Brant Hamel

1

1 reference

4 August 2017

Elizabeth Monaghan-Benson

2

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4 August 2017

Rafael J Rojas

3

1 reference

4 August 2017

Brenda R S Temple

4

1 reference

4 August 2017

Daniel J Marston

5

1 reference

4 August 2017

Keith Burridge

6

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4 August 2017

language of work or name

English

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publication date

17 January 2011

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Journal of Biological Chemistry

4 August 2017

published in

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4 August 2017

volume

286

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4 August 2017

issue

14

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4 August 2017

page(s)

12141-12148

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Splice variants of SmgGDS control small GTPase prenylation and membrane localization

4 August 2017

cites work

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7 July 2018

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Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

7 July 2018

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SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells

7 July 2018

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7 July 2018

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Crystal Structure of a Full-Length β-Catenin

7 July 2018

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SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma

7 July 2018

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7 July 2018

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Rho GTPases in animal cell mitosis

7 July 2018

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

7 July 2018

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RAS and RHO GTPases in G1-phase cell-cycle regulation

7 July 2018

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Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes

7 July 2018

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The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences

7 July 2018

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7 July 2018

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Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases

7 July 2018

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7 July 2018

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XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

7 July 2018

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Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.

7 July 2018

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A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site

7 July 2018

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Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

7 July 2018

1 reference

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The role of Rho GTPases and associated kinases in regulating neurite outgrowth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

SmgGDS displays differential binding and exchange activity towards different Ras isoforms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

7 July 2018

1 reference

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

7 July 2018

1 reference

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VERIFY3D: assessment of protein models with three-dimensional profiles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

A repeating amino acid motif shared by proteins with diverse cellular roles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

Partial purification and characterization of GDP dissociation stimulator (GDS) for the rho proteins from bovine brain cytosol.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069418

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.191122

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.191122

betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.191122

Role of the C-terminal region of smg p21, a ras p21-like small GTP-binding protein, in membrane and smg p21 GDP/GTP exchange protein interactions

21 January 2018

1 reference

12 December 2020

The Dbl oncogene product as a GDP/GTP exchange protein for the Rho family: its properties in comparison with those of Smg GDS

1 reference

12 December 2020

RhoB can adopt a Mg2+free conformation prior to GEF binding

1 reference

12 December 2020

Mechanism of nucleotide release from Rho by the GDP dissociation stimulator protein

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.191122

1 reference

4 August 2017

1 reference

4 August 2017

1 reference