(Q26825704)

title

Epigenetic regulation by histone demethylases in hypoxia (English)

1 reference

0 references

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Rebecca L Hancock

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Louise J. Walport

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Emily Flashman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Kate Dunne

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

1 reference

August 2015

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

7

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

5

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

791-811

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

7 June 2020

cites work

1 reference

REDOX regulation of early embryo development.

21 January 2018

1 reference

The impact of O2 availability on human cancer

21 January 2018

1 reference

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

21 January 2018

1 reference

Prolyl 4-hydroxylases, master regulators of the hypoxia response

21 January 2018

1 reference

Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

21 January 2018

1 reference

The human oxygen sensing machinery and its manipulation

21 January 2018

1 reference

HIF-1 and HIF-2 transcription factors--similar but not identical

21 January 2018

1 reference

Chromatin modifications and their function

21 January 2018

1 reference

Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth

21 January 2018

1 reference

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

21 January 2018

1 reference

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

21 January 2018

1 reference

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity.

21 January 2018

1 reference

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

21 January 2018

1 reference

Structural studies on human 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

21 January 2018

1 reference

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.

21 January 2018

1 reference

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

21 January 2018

1 reference

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

21 January 2018

1 reference

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

21 January 2018

1 reference

Kinetic analysis of iron-dependent histone demethylases: α-ketoglutarate substrate inhibition and potential relevance to the regulation of histone demethylation in cancer cells

21 January 2018

1 reference

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

21 January 2018

1 reference

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

21 January 2018

1 reference

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

21 January 2018

1 reference

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).

21 January 2018

1 reference

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

21 January 2018

1 reference

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

21 January 2018

1 reference

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

21 January 2018

1 reference

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

21 January 2018

1 reference

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

21 January 2018

1 reference

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

21 January 2018

1 reference

The language of covalent histone modifications

21 January 2018

1 reference

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

Molecular mechanisms and potential functions of histone demethylases

21 January 2018

1 reference

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

1 reference

Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

1 reference

The SET-domain protein superfamily: protein lysine methyltransferases

21 January 2018

1 reference

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

21 January 2018

1 reference

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

21 January 2018

1 reference

Structural insights into histone demethylation by JMJD2 family members.

21 January 2018

1 reference

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

21 January 2018

1 reference

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

21 January 2018

1 reference

JmjC-domain-containing proteins and histone demethylation

21 January 2018

1 reference

Histone lysine demethylases as targets for anticancer therapy

21 January 2018

1 reference

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

21 January 2018

1 reference

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

21 January 2018

1 reference

Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases

21 January 2018

1 reference

HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions

21 January 2018

1 reference

The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.

21 January 2018

1 reference

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

21 January 2018

1 reference

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

21 January 2018

1 reference

The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.

21 January 2018

1 reference

Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases

21 January 2018

1 reference

Chromatin and oxygen sensing in the context of JmjC histone demethylases

21 January 2018

1 reference

Hypoxia enhances the expression of prostate-specific antigen by modifying the quantity and catalytic activity of Jumonji C domain-containing histone demethylases

21 January 2018

1 reference

Nickel carcinogenesis: epigenetics and hypoxia signaling

21 January 2018

1 reference

Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms

21 January 2018

1 reference

Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells

21 January 2018

1 reference

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

21 January 2018

1 reference

Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase

21 January 2018

1 reference

Enhanced trimethylation of histone h3 mediates impaired expression of hepatic glucose 6-phosphatase expression in offspring from rat dams exposed to hypoxia during pregnancy

21 January 2018

1 reference

Epigenetics: new questions on the response to hypoxia

21 January 2018

1 reference

Chromatin as an oxygen sensor and active player in the hypoxia response.

21 January 2018

1 reference

Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α.

21 January 2018

1 reference

The role of hypoxia in development of the Mammalian embryo

21 January 2018

1 reference

The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus--a review

21 January 2018

1 reference

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

21 January 2018

1 reference

Return to the fetal gene program: a suggested metabolic link to gene expression in the heart

21 January 2018

1 reference

Metabolic gene expression in fetal and failing human heart

21 January 2018

1 reference

Return to the fetal gene program protects the stressed heart: a strong hypothesis

21 January 2018

1 reference

Hypoxia and fetal heart development.

21 January 2018

1 reference

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

21 January 2018

1 reference

Bivalent histone modifications in early embryogenesis

21 January 2018

1 reference

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.

21 January 2018

1 reference

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

21 January 2018

1 reference

Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo

21 January 2018

1 reference

Chromatin signature of embryonic pluripotency is established during genome activation

21 January 2018

1 reference

Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos

21 January 2018

1 reference

A view of bivalent epigenetic marks in two human embryonic stem cell lines reveals a different cardiogenic potential.

21 January 2018

1 reference

A double take on bivalent promoters

21 January 2018

1 reference

Epigenetic regulation of Hox gene activation: the waltz of methyls

21 January 2018

1 reference

Bivalent histone modifications during tooth development

21 January 2018

1 reference

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

21 January 2018

1 reference

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

21 January 2018

1 reference

Developmental roles of the histone lysine demethylases

21 January 2018

1 reference

Histone demethylases in development and disease

21 January 2018

1 reference

Epigenetic regulation of development by histone lysine methylation.

21 January 2018

1 reference

The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development

21 January 2018

1 reference

Spatiotemporal expression of DNA demethylation enzymes and histone demethylases in bovine embryos

21 January 2018

1 reference

Novel KDM6A (UTX) mutations and a clinical and molecular review of the X-linked Kabuki syndrome (KS2).

21 January 2018

1 reference

A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

21 January 2018

1 reference

A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability.

21 January 2018

1 reference

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

21 January 2018

1 reference

The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators

21 January 2018

1 reference

KDM2B is implicated in bovine lethal multi-organic developmental dysplasia

21 January 2018

1 reference

Prevalence of paunch calf syndrome carriers in Italian Romagnola cattle.

21 January 2018

1 reference

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a

21 January 2018

1 reference

The histone demethylase Kdm3a is essential to progression through differentiation

21 January 2018

1 reference

Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling

21 January 2018

1 reference

Jarid1b targets genes regulating development and is involved in neural differentiation

21 January 2018

1 reference

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3

21 January 2018

1 reference

A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX

21 January 2018

1 reference

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

21 January 2018

1 reference

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

21 January 2018

1 reference

The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment

21 January 2018

1 reference

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

21 January 2018

1 reference

Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.

21 January 2018

1 reference

Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells.

21 January 2018

1 reference

Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells

21 January 2018

1 reference

UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program

21 January 2018

1 reference

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

21 January 2018

1 reference

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

21 January 2018

1 reference

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

21 January 2018

1 reference

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

21 January 2018

1 reference

Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4.

21 January 2018

1 reference

On the Origin of Cancer Cells

21 January 2018

1 reference

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

Histone methylation: a dynamic mark in health, disease and inheritance

21 January 2018

1 reference

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene

21 January 2018

1 reference

The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia

21 January 2018

1 reference

Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells

21 January 2018

1 reference

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

1 reference

Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.

21 January 2018

1 reference

KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells

21 January 2018

1 reference

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

1 reference

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

21 January 2018

1 reference

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

21 January 2018

1 reference

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

21 January 2018

1 reference

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

21 January 2018

1 reference

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

21 January 2018

1 reference

Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.

21 January 2018

1 reference

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

21 January 2018

1 reference

Expression and significance of histone H3K27 demethylases in renal cell carcinoma

21 January 2018

1 reference

The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

21 January 2018

1 reference

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

21 January 2018

1 reference

Inhibitors of histone demethylases

21 January 2018

1 reference

Inhibition of 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

Targeting histone lysine demethylases - progress, challenges, and the future

21 January 2018

1 reference

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

21 January 2018

1 reference

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

21 January 2018

1 reference

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

21 January 2018

1 reference

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

21 January 2018

1 reference

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

1 reference

Inhibition of demethylases by GSK-J1/J4.

21 January 2018

1 reference

Genetics and epigenetics of arrhythmia and heart failure

21 January 2018

1 reference

Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure

21 January 2018

1 reference

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

21 January 2018

1 reference

PET imaging of cardiac hypoxia: opportunities and challenges.

21 January 2018

1 reference

Genome-wide histone methylation profile for heart failure

21 January 2018

1 reference

Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes.

21 January 2018

1 reference

The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice

21 January 2018

1 reference

Distinct epigenomic features in end-stage failing human hearts

21 January 2018

1 reference

HDAC4 controls histone methylation in response to elevated cardiac load

21 January 2018

1 reference

Epigenetics in the heart: the role of histone modifications in cardiac remodelling

21 January 2018

1 reference

Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy.

21 January 2018

1 reference

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

21 January 2018

1 reference

The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice

21 January 2018

1 reference

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

21 January 2018

1 reference

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

21 January 2018

1 reference

Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages.

21 January 2018

1 reference

Serum amyloid A in atherosclerosis

21 January 2018

1 reference

Arterial thrombus formation in cardiovascular disease

21 January 2018

1 reference

The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility

21 January 2018

1 reference

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development

21 January 2018

1 reference

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

21 January 2018

1 reference

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

21 January 2018

1 reference

Generation of an epigenetic signature by chronic hypoxia in prostate cells

21 January 2018

1 reference

Induction of DNA hypomethylation by tumor hypoxia.

21 January 2018

1 reference

Stopped-Flow Kinetic Analysis ofEscherichia coliTaurine/α-Ketoglutarate Dioxygenase: Interactions with α-Ketoglutarate, Taurine, and Oxygen†

21 January 2018

1 reference

HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages

21 January 2018

1 reference

7 January 2021

Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta

1 reference

7 January 2021

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

7 January 2021

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

1 reference

7 January 2021

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

1 reference

7 January 2021

Functional genomics: Complexities of occupancy and sequence

1 reference

7 January 2021

Epigenetics in heart failure

1 reference

7 January 2021

Hyperoxia reduces bone marrow, circulating, and lung endothelial progenitor cells in the developing lung: implications for the pathogenesis of bronchopulmonary dysplasia

1 reference

7 January 2021

Development of cardiac sensitivity to oxygen deficiency: comparative and ontogenetic aspects

1 reference

7 January 2021

Evidence of hypoxic areas within the arterial wall in vivo

1 reference

7 January 2021

Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection

1 reference

7 January 2021

Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits

1 reference

7 January 2021

Identifiers

DOI

10.2217/EPI.15.24

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json

release_n2vnvkl5qrck5gv3fnrglasja4

7 June 2020

Fatcat ID

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25832587%20AND%20SRC:MED&resulttype=core&format=json