(Q27316616)

26 June 2017

title

Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations (English)

1 reference

26 June 2017

Neil Peterman

1

1 reference

26 June 2017

Erel Levine

series ordinal

2

1 reference

26 June 2017

language of work or name

English

0 references

publication date

9 March 2016

1 reference

26 June 2017

1 reference

26 June 2017

volume

17

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26 June 2017

issue

1

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page(s)

206

1 reference

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

26 June 2017

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1 reference

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Experimental illumination of a fitness landscape

21 March 2017

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Stochastic gene expression in a single cell

21 March 2017

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An excitable gene regulatory circuit induces transient cellular differentiation

21 March 2017

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Bacterial persistence as a phenotypic switch

21 March 2017

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High-throughput cellular RNA device engineering.

7 April 2017

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Systematic dissection of the sequence determinants of gene 3' end mediated expression control

28 September 2017

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Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface.

28 September 2017

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Massively parallel single-amino-acid mutagenesis

28 September 2017

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A systematic survey of an intragenic epistatic landscape.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Viewing protein fitness landscapes through a next-gen lens.

28 September 2017

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Large-scale mapping of sequence-function relations in small regulatory RNAs reveals plasticity and modularity

28 September 2017

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High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions

28 September 2017

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Quantitative analysis of mammalian translation initiation sites by FACS-seq

28 September 2017

1 reference

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Saturation editing of genomic regions by multiplex homology-directed repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Deep mutational scanning: a new style of protein science

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Probing the effect of promoters on noise in gene expression using thousands of designed sequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

In pursuit of design principles of regulatory sequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Empirical fitness landscapes and the predictability of evolution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Inferring fitness landscapes by regression produces biased estimates of epistasis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Large-scale de novo DNA synthesis: technologies and applications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Function-based identification of mammalian enhancers using site-specific integration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Systematic identification of regulatory elements in conserved 3' UTRs of human transcripts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Massively parallel functional annotation of 3' untranslated regions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Parametric inference in the large data limit using maximally informative models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Causes and effects of N-terminal codon bias in bacterial genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Composability of regulatory sequences controlling transcription and translation in Escherichia coli

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Deciphering the rules by which 5'-UTR sequences affect protein expression in yeast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Massive functional mapping of a 5'-UTR by saturation mutagenesis, phenotypic sorting and deep sequencing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Genome-wide quantitative enhancer activity maps identified by STARR-seq

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Complex effects of nucleotide variants in a mammalian cis-regulatory element.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

The spatial architecture of protein function and adaptation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Massively parallel functional dissection of mammalian enhancers in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

High-resolution mapping of protein sequence-function relationships

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Analysis of a complete DNA-protein affinity landscape

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Quantitative phenotyping via deep barcode sequencing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Precise physical models of protein-DNA interaction from high-throughput data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Rapid Construction of Empirical RNA Fitness Landscapes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4784318

Evolvability as a function of purifying selection in TEM-1 β-lactamase

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12864-016-2533-5

Universal protein fluctuations in populations of microorganisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12864-016-2533-5

Phenotypic diversity, population growth, and information in fluctuating environments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12864-016-2533-5

Gene expression. MicroRNA control of protein expression noise

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12864-016-2533-5

10.1186/S12864-016-2533-5

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

26 June 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12864-016-2533-5

PMC publication ID

4784318

0 references

1 reference