(Q27650628)

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Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity

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scholarly article

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Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity (English)

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Ronen Marmorstein

9

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8

object named as

Eric Meggers

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Meenhard Herlyn

7

object named as

Meenhard Herlyn

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Keiran S M Smalley

6

object named as

Keiran S M Smalley

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author name string

Peng Xie

1

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Douglas S Williams

2

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G Ekin Atilla-Gokcumen

3

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Leslie Milk

4

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Min Xiao

5

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publication date

16 May 2008

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ACS Chemical Biology

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3

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305-16

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5

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2 references

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The CCP4 suite: programs for protein crystallography

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High frequency of mutations of the PIK3CA gene in human cancers

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Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

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Ruthenium half-sandwich complexes bound to protein kinase Pim-1

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

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Phosphoinositide kinases

1 reference

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

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Cancer-specific mutations in phosphatidylinositol 3-kinase

1 reference

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Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety

1 reference

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Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3.

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1 reference

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Deregulated Akt3 activity promotes development of malignant melanoma

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Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

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Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1 reference

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based on heuristic

inferred from PubMed ID database lookup

An organometallic inhibitor for glycogen synthase kinase 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/18484710

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inferred from PubMed ID database lookup

Platinum complex as a nanomolar protein kinase inhibitor

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CB800039Y

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