(Q27657380)

English

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].

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Europe PubMed Central

PubMed publication ID

22 June 2017

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. (English)

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22 June 2017

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Yves Pommier

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22 June 2017

author name string

Andrew G Jobson

1

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22 June 2017

George T Lountos

2

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22 June 2017

Philip L Lorenzi

3

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22 June 2017

Jenny Llamas

4

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22 June 2017

John Connelly

5

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22 June 2017

David Cerna

6

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22 June 2017

Joseph E Tropea

7

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22 June 2017

Akikazu Onda

8

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22 June 2017

Gabriele Zoppoli

9

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22 June 2017

Sudhir Kondapaka

10

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22 June 2017

Guangtao Zhang

11

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22 June 2017

Natasha J Caplen

12

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22 June 2017

John H Cardellina

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22 June 2017

Stephen S Yoo

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22 June 2017

Anne Monks

15

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22 June 2017

Christopher Self

16

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22 June 2017

David S Waugh

17

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22 June 2017

Robert H Shoemaker

18

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22 June 2017

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publication date

9 September 2009

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22 June 2017

Journal of Pharmacology and Experimental Therapeutics

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22 June 2017

331

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22 June 2017

3

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22 June 2017

816-826

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22 June 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2784710/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

1 reference

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20 March 2017

Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

20 March 2017

The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication

1 reference

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20 March 2017

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

20 March 2017

The protein kinase complement of the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

20 March 2017

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

20 March 2017

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

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20 March 2017

Cell cycle kinases as therapeutic targets for cancer

1 reference

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20 March 2017

BRCA1 is regulated by Chk2 in response to spindle damage

1 reference

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20 March 2017

Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

1 reference

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20 March 2017

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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7 April 2017

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

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7 April 2017

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

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7 April 2017

Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways

1 reference

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29 September 2017

DNA damage induces two distinct modes of cell death in ovarian carcinomas

1 reference

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29 September 2017

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

1 reference

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Activated checkpoint kinase 2 provides a survival signal for tumor cells

1 reference

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Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

1 reference

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29 September 2017

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

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Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

1 reference

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Structural biology in drug design: selective protein kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

29 September 2017

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

1 reference

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29 September 2017

Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

29 September 2017

Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.

1 reference

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The structure-based design of ATP-site directed protein kinase inhibitors

1 reference

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29 September 2017

Molecular interaction map of the mammalian cell cycle control and DNA repair systems

1 reference

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29 September 2017

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

1 reference

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

1 reference

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Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

27 November 2018

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

27 November 2018

Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles

1 reference

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27 November 2018

Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

27 November 2018

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784710

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UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

1 reference

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Chk2 molecular interaction map and rationale for Chk2 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19741151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel, selective and potent Chk2 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19741151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19741151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keeping checkpoint kinases in line: new selective inhibitors in clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/19741151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19741151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.109.154997

1 reference

Europe PubMed Central

PubMed publication ID

22 June 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 June 2017

ResearchGate publication ID

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