(Q27657884)

2

0 references

Leslie A Bush-Pelc

3

0 references

Alaji Bah

4

0 references

Prafull S Gandhi

5

0 references

Enrico Di Cera

Journal of Biological Chemistry

6

0 references

language of work or name

English

0 references

publication date

25 December 2009

0 references

published in

0 references

volume

284

0 references

issue

52

0 references

page(s)

36175-85

0 references

cites work

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Stabilization of the E* Form Turns Thrombin into an Anticoagulant

20 March 2017

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Crystal structure of a translation termination complex formed with release factor RF2

20 March 2017

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Na+ binding to meizothrombin desF1

20 March 2017

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Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

20 March 2017

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Structural identification of the pathway of long-range communication in an allosteric enzyme

20 March 2017

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Structure of human pro-chymase: a model for the activating transition of granule-associated proteases

20 March 2017

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High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop

20 March 2017

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Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole

20 March 2017

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Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops

20 March 2017

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Crystal structure reveals basis for the inhibitor resistance of human brain trypsin

20 March 2017

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Unexpected crucial role of residue 225 in serine proteases

20 March 2017

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The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases

20 March 2017

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The molecular environment of the Na+ binding site of thrombin

20 March 2017

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Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution

20 March 2017

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Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution

20 March 2017

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Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

20 March 2017

1 reference

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Refined structure of the hirudin-thrombin complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Stereochemical quality of protein structure coordinates

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Serine protease mechanism and specificity

20 March 2017

1 reference

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Structural basis of substrate specificity in the serine proteases

7 April 2017

1 reference

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7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Serine peptidases: classification, structure and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Role of Na+ and K+ in enzyme function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

A structural perspective on enzymes activated by monovalent cations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Crystal structure of wild-type human thrombin in the Na+-free state.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Redesigning the monovalent cation specificity of an enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

MDB: the Metalloprotein Database and Browser at The Scripps Research Institute

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Sodium binding site of factor Xa: role of sodium in the prothrombinase complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

The crystal structure of the mouse glandular kallikrein-13 (prorenin converting enzyme).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Protein metal-binding sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. I. Crystallization, data collection and application of patterson search technique

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Molecular mechanisms of thrombin function

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Conversion of thrombin into an anticoagulant by protein engineering

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Kinetics and mechanism of catalysis by proteolytic enzymes. 2. Kinetic studies of thrombin-catalysed reactions and their modification by bile salts and other detergents

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Effect of monovalent cations on the pre-steady-state kinetic parameters of the plasma protease bovine activated protein C.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Kinetic mechanism for stimulation by monovalent cations of the amidase activity of the plasma protease bovine activated protein C.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Thrombin is a Na(+)-activated enzyme

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

The effect of metal ions on the amidolytic activity of human factor Xa (Activated Stuart-Prower Factor)

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Thermodynamics of Na+ binding to coagulation serine proteases

19 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

An extensive interaction interface between thrombin and factor V is required for factor V activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Molecular dissection of Na+ binding to thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Dissecting substrate recognition by thrombin using the inactive mutant S195A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Use of a fluorescence plate reader for measuring kinetic parameters with inner filter effect correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Mechanism of charge compensation and impairment of co-operative functions in haemoglobin Tacoma (Arg B12(30)β → ser)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.069500

Prothrombin Scranton: substitution of an amino acid residue involved in the binding of Na+ (LYS-556 to THR) leads to dysprothrombinemia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794733

Identification of a binding site for quaternary amines in factor Xa

27 November 2018

1 reference

12 December 2020

Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human coagulation factor xa. Studies on catalytic efficiency and inhibitor binding

1 reference

12 December 2020

Rational design of a potent anticoagulant thrombin

1 reference

12 December 2020

Role of residue Phe225 in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor VIIa

1 reference

12 December 2020

Molecular mapping of thrombin-receptor interactions

1 reference

12 December 2020

Kinetic analysis of enzyme reactions. II. The potassium activation and calcium inhibition of pyruvic phosphoferase.

1 reference

12 December 2020

Structure and activation of trypsinogen and chymotrypsinogen

1 reference

12 December 2020

[Purification and properties of the beta-galactosidase (lactase) of Escherichia coli]

1 reference

12 December 2020

Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand

1 reference

12 December 2020

Prothrombin Saint-Denis: a natural variant with a point mutation resulting in Asp to Glu substitution at position 552 in prothrombin

1 reference

12 December 2020

High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form

1 reference

12 December 2020

Prothrombin deficiency caused by compound heterozygosity for two novel mutations in the prothrombin gene associated with a bleeding tendency

1 reference

12 December 2020

Crystal structure of thrombin in a self-inhibited conformation

1 reference

12 December 2020

Rapid kinetics of Na+ binding to thrombin

1 reference

12 December 2020

Role of the alpha-helix 163-170 in factor Xa catalytic activity

1 reference

12 December 2020

Conformational equilibria in -and -chymotrypsin. The energetics and importance of the salt bridge

1 reference

12 December 2020

Equilibrium and rate constants for the interconversion of two conformations of -chymotrypsin. The existence of a catalytically inactive conformation at neutral p H

1 reference

12 December 2020

Enzymes activated by monovalent cations

1 reference

12 December 2020

The effect of monovalent cations on the catalytic activity of thrombin

1 reference

12 December 2020

Stimulation of the amidase and esterase activity of activated bovine plasma protein C by monovalent cations

1 reference

12 December 2020

Kinetic studies of the role of monovalent cations in the amidolytic activity of activated bovine plasma protein C

1 reference

12 December 2020

Modeling coordination sites in metallobiomolecules

1 reference

12 December 2020

Evidence that human alpha-thrombin is a monovalent cation-activated enzyme

1 reference

12 December 2020

The Na+ binding site of thrombin

1 reference

12 December 2020

Release of fibrinopeptides by the slow and fast forms of thrombin

1 reference

12 December 2020

Large heat capacity change in a protein-monovalent cation interaction

1 reference

12 December 2020

Rational engineering of activity and specificity in a serine protease

1 reference

12 December 2020

Selective loss of fibrinogen clotting in a loop-less thrombin

1 reference

12 December 2020

Kinetic pathway for the slow to fast transition of thrombin. Evidence of linked ligand binding at structurally distinct domains

1 reference

12 December 2020

Prothrombin Greenville, Arg517-->Gln, identified in an individual heterozygous for dysprothrombinemia

1 reference

12 December 2020

Identification and characterization of the sodium-binding site of activated protein C

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.069500

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

30 July 2022

release_yp4iityo7bd2bewnmwujbkc22u

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

30 July 2022

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

1 reference

30 July 2022