(Q36538526)

14 August 2017

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation (English)

1 reference

14 August 2017

5

Paul E Bock

1 reference

14 August 2017

Heather K Kroh

1

1 reference

14 August 2017

Guido Tans

series ordinal

2

1 reference

14 August 2017

Gerry A F Nicolaes

series ordinal

3

1 reference

14 August 2017

Jan Rosing

series ordinal

4

1 reference

14 August 2017

language of work or name

English

0 references

publication date

12 April 2007

1 reference

14 August 2017

10

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

14 August 2017

282

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14 August 2017

22

1 reference

14 August 2017

16095-16104

1 reference

Structure and interaction modes of thrombin

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Determinants of specificity in coagulation proteases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Molecular recognition mechanisms of thrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

The structure of thrombin, a chameleon-like proteinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Thrombin: a paradigm for enzymes allosterically activated by monovalent cations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Exosite-driven substrate specificity and function in coagulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Proexosite-1 on Prothrombin Is a Factor Va-dependent Recognition Site for the Prothrombinase Complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Crystal structure of the anticoagulant slow form of thrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Sodium binding site of factor Xa: role of sodium in the prothrombinase complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

The molecular environment of the Na+ binding site of thrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Theory of allosteric effects in serine proteases.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Characterization of a stable form of human meizothrombin derived from recombinant prothrombin (R155A, R271A, and R284A).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

On the size of the active site in proteases. I. Papain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Human thrombins. Production, evaluation, and properties of alpha-thrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

The Contribution of Amino Acid Region Asp695-Tyr698 of Factor V to Procofactor Activation and Factor Va Function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Molecular mechanisms of thrombin function

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Formation of meizothrombin as intermediate in factor Xa-catalyzed prothrombin activation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Thrombin is a Na(+)-activated enzyme

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate

28 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Molecular dissection of Na+ binding to thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

An extensive interaction interface between thrombin and factor V is required for factor V activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Thermodynamics of Na+ binding to coagulation serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610577200

Activation of human factor V by meizothrombin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Inhibition of thrombin-catalyzed factor V activation by bothrojaracin

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2292469

Rapid kinetics of Na+ binding to thrombin

4 December 2018

1 reference

12 December 2020

Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation

1 reference

12 December 2020

Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites

1 reference

12 December 2020

The contribution of factor Xa to exosite-dependent substrate recognition by prothrombinase

1 reference

12 December 2020

1 reference

12 December 2020

Meizothrombin, a major product of factor Xa-catalyzed prothrombin activation

1 reference

12 December 2020

Isolation of human blood coagulation alpha-factor Xa by soybean trypsin inhibitor-sepharose chromatography and its active-site titration with fluorescein mono-p-guanidinobenzoate

1 reference

12 December 2020

Multiple active forms of thrombin. IV. Relative activities of meizothrombins

1 reference

12 December 2020

Meizothrombin formation during factor Xa-catalyzed prothrombin activation. Formation in a purified system and in plasma

1 reference

12 December 2020

Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. I. Specificity of thrombin labeling

1 reference

12 December 2020

Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. II. Properties of thrombin derivatives as reporters of prothrombin fragment 2 binding and specificity of t

1 reference

12 December 2020

Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII

1 reference

12 December 2020

Large heat capacity change in a protein-monovalent cation interaction

1 reference

12 December 2020

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

1 reference

12 December 2020

Exosites determine macromolecular substrate recognition by prothrombinase

1 reference

12 December 2020

Kinetic pathway for the slow to fast transition of thrombin. Evidence of linked ligand binding at structurally distinct domains

1 reference

12 December 2020

Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex

1 reference

12 December 2020

Demonstration of exosite I-dependent interactions of thrombin with human factor V and factor Va involving the factor Va heavy chain: analysis by affinity chromatography employing a novel method for active-site-selective immobilization of serine prot

1 reference

12 December 2020

Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments

1 reference

12 December 2020

High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form

1 reference

12 December 2020

Crystal structure of thrombin in a self-inhibited conformation

1 reference

12 December 2020

Characterization of proexosite I on prothrombin

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M610577200

1 reference

14 August 2017

1 reference

14 August 2017

1 reference