(Q27684072)

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Anne Cleasby

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Jeff Yon

2

1 reference

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6 June 2020

Philip J Day

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Caroline Richardson

4

1 reference

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6 June 2020

Pamela A Williams

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

James F Callahan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Robin Carr

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Nestor Concha

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Jeffrey K Kerns

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Hongwei Qi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Thomas Sweitzer

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Paris Ward

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Thomas G Davies

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

language of work or name

English

0 references

publication date

2014

0 references

published in

PLOS One

1 reference

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6 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

e98896

1 reference

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Creative Commons Attribution 4.0 International

6 June 2020

copyright license

start time

4 June 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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20 March 2017

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

20 March 2017

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

20 March 2017

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20 March 2017

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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

20 March 2017

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

20 March 2017

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20 March 2017

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Overview of the CCP4 suite and current developments

20 March 2017

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20 March 2017

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20 March 2017

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Clustal W and Clustal X version 2.0

20 March 2017

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Scaling and assessment of data quality

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

20 March 2017

1 reference

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The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

20 March 2017

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Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

20 March 2017

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Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

20 March 2017

1 reference

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Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

20 March 2017

1 reference

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The cancer chemopreventive actions of phytochemicals derived from glucosinolates

20 March 2017

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Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

20 March 2017

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

20 March 2017

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

20 March 2017

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Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

20 March 2017

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

20 March 2017

1 reference

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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

7 April 2017

1 reference

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

7 April 2017

1 reference

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

7 April 2017

1 reference

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

7 April 2017

1 reference

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Crystal structure of KLHL3 in complex with Cullin3

7 April 2017

1 reference

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Bardoxolone methyl and kidney function in CKD with type 2 diabetes

29 September 2017

1 reference

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Fragment screening using X-ray crystallography.

29 September 2017

1 reference

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Modification of keap1 cysteine residues by sulforaphane

29 September 2017

1 reference

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

29 September 2017

1 reference

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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Targeting the Nrf2 pathway against cardiovascular disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Prospective type 1 and type 2 disulfides of Keap1 protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Sites of alkylation of human Keap1 by natural chemoprevention agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Chemopreventive promise of targeting the Nrf2 pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Automated protein-ligand crystallography for structure-based drug design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

AstexViewer: a visualisation aid for structure-based drug design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Functional antioxidant responsive elements.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045772

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Keap calm, and carry on covalently

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Chiral decalins: preparation from oleanolic acid and application in the synthesis of (-)-9-epi-ambrox.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0098896

Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24896564

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1242/JCS.074286

Identifiers

DOI

10.1371/JOURNAL.PONE.0098896

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

24896564

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896564%20AND%20SRC:MED&resulttype=core&format=json