(Q27702518)

5

0 references

Eugene Muratov

13

0 references

Denis Fourches

12

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John P. Overington

21

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Ayman Al Haj Zen

Ayman Al Haj Zen

11

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David Drewry

David H Drewry

26

0 references

Jonathan M Elkins

Jonathan M Elkins

1

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Susanne Müller

Susanne Müller

23

0 references

Stefan Knapp

Stefan Knapp

27

0 references

Francis Atkinson

Francis L Atkinson

20

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Bryan L. Roth

10

Bryan L Roth

0 references

Marta Szklarz

3

Marta Szklarz

0 references

Vita Fedele

2

Vita Fedele

0 references

Kamal R. Abdul Azeez

4

Kamal R Abdul Azeez

0 references

William J Zuercher

28

William J Zuercher

0 references

Timothy M Willson

25

Timothy M Willson

0 references

author name string

Jowita Mikolajczyk

6

0 references

Sergei Romanov

7

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Nikolai Sepetov

8

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Xi-Ping Huang

9

0 references

Alex Tropsha

14

0 references

Joel Morris

15

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Beverly A Teicher

16

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Mark Kunkel

17

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Eric Polley

18

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Karen E Lackey

19

0 references

Daniel J Price

Open access chemical and clinical probes to support drug discovery

24

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publication date

January 2016

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published in

Nature Biotechnology

0 references

volume

34

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issue

1

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page(s)

95-103

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cites work

1 reference

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

21 April 2017

1 reference

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

21 April 2017

1 reference

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

21 April 2017

1 reference

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation

21 April 2017

1 reference

LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes

21 April 2017

1 reference

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

21 April 2017

1 reference

The selectivity of protein kinase inhibitors: a further update

21 April 2017

1 reference

A quantitative analysis of kinase inhibitor selectivity

21 April 2017

1 reference

Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays

21 April 2017

1 reference

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

21 April 2017

1 reference

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment

21 April 2017

1 reference

Structural Features for Functional Selectivity at Serotonin Receptors

21 April 2017

1 reference

Targeting cancer with small molecule kinase inhibitors

21 April 2017

1 reference

Global mapping of pharmacological space

21 April 2017

1 reference

The NCI60 human tumour cell line anticancer drug screen

21 April 2017

1 reference

Angiogenesis: an organizing principle for drug discovery?

21 April 2017

1 reference

VEGF receptor signalling - in control of vascular function

21 April 2017

1 reference

Comprehensive analysis of kinase inhibitor selectivity

21 April 2017

1 reference

A small molecule-kinase interaction map for clinical kinase inhibitors

21 April 2017

1 reference

Using Graph Indices for the Analysis and Comparison of Chemical Datasets

21 April 2017

1 reference

12 December 2020

FDA-approved small-molecule kinase inhibitors.

1 reference

12 December 2020

Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2

1 reference

12 December 2020

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

1 reference

12 December 2020

Molecular basis for sunitinib efficacy and future clinical development

1 reference

12 December 2020

An information-intensive approach to the molecular pharmacology of cancer.

1 reference

12 December 2020

Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

1 reference

12 December 2020

Kinase inhibitor selectivity profiling using differential scanning fluorimetry

1 reference

12 December 2020

In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract

1 reference

12 December 2020

Automated design of ligands to polypharmacological profiles.

1 reference

12 December 2020

Navigating the kinome

1 reference

12 December 2020

Kinase drug discovery--what's next in the field?

1 reference

12 December 2020

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

12 December 2020

A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases

1 reference

12 December 2020

Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors.

1 reference

12 December 2020

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

1 reference

12 December 2020

Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.

1 reference

12 December 2020

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells

1 reference

12 December 2020

System-based drug discovery within the human kinome

1 reference

12 December 2020

Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)

1 reference

12 December 2020

Trends in kinase selectivity: insights for target class-focused library screening

1 reference

12 December 2020

Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell lines

1 reference

12 December 2020

The (un)targeted cancer kinome

1 reference

12 December 2020

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

1 reference

12 December 2020

The purinome, a complex mix of drug and toxicity targets

1 reference

12 December 2020

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

1 reference

12 December 2020

An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.

1 reference

12 December 2020

The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

1 reference

12 December 2020

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

1 reference

12 December 2020

Probing the probes: fitness factors for small molecule tools

1 reference

12 December 2020

Analysis of cell-based RNAi screens.

1 reference

12 December 2020

Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition

1 reference

12 December 2020

Features of selective kinase inhibitors

1 reference

12 December 2020

CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.

1 reference

12 December 2020