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The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF
scientific article
The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
25056119
retrieved
13 November 2016
title
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF
(English)
1 reference
stated in
PubMed
PubMed ID
25056119
retrieved
13 November 2016
main subject
pharmacology
1 reference
based on heuristic
inferred from title
author
Lynda Chin
series ordinal
14
0 references
Gordon B. Mills
series ordinal
13
object named as
Gordon B Mills
0 references
author name string
Ian R Watson
series ordinal
1
0 references
Liren Li
series ordinal
2
0 references
Peter K Cabeceiras
series ordinal
3
0 references
Mozhdeh Mahdavi
series ordinal
4
0 references
Tony Gutschner
series ordinal
5
0 references
Giannicola Genovese
series ordinal
6
0 references
Guocan Wang
series ordinal
7
0 references
Zhuangna Fang
series ordinal
8
0 references
James M Tepper
series ordinal
9
0 references
Katherine Stemke-Hale
series ordinal
10
0 references
Kenneth Y Tsai
series ordinal
11
0 references
Michael A Davies
series ordinal
12
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language of work or name
English
0 references
publication date
1 September 2014
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published in
Cancer Research
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volume
74
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page(s)
4845-52
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issue
17
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cites work
A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition
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PubMed Central
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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
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20 March 2017
RAC1P29S is a spontaneously activating cancer-associated GTPase
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PubMed Central
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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
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PubMed Central
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20 March 2017
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
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A landscape of driver mutations in melanoma
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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
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PubMed Central
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Improved survival with vemurafenib in melanoma with BRAF V600E mutation
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20 March 2017
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
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PubMed Central
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20 March 2017
MEK1 mutations confer resistance to MEK and B-RAF inhibition
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20 March 2017
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
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Rho GTPases: biochemistry and biology
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Mutations of the BRAF gene in human cancer
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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
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Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
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7 April 2017
Improved survival with MEK inhibition in BRAF-mutated melanoma
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7 April 2017
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
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The mutational landscape of head and neck squamous cell carcinoma
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7 April 2017
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
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Emerging insights into resistance to BRAF inhibitors in melanoma
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29 September 2017
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
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PubMed Central
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29 September 2017
MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition
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PubMed Central
reference URL
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29 September 2017
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
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29 September 2017
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
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PubMed Central
reference URL
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29 September 2017
C-RAF mutations confer resistance to RAF inhibitors
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PubMed Central
reference URL
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29 September 2017
Transforming mutations of RAC guanosine triphosphatases in human cancers
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29 September 2017
Resistance to BRAF-targeted therapy in melanoma
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PubMed Central
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29 September 2017
Integrative functional genomics identifies RINT1 as a novel GBM oncogene
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29 September 2017
Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors
1 reference
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PubMed Central
reference URL
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29 September 2017
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation
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PubMed Central
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29 September 2017
Rac signaling in breast cancer: a tale of GEFs and GAPs.
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PubMed Central
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29 September 2017
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167745
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29 September 2017
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167745
retrieved
29 September 2017
Identifiers
DOI
10.1158/0008-5472.CAN-14-1232-T
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2143714
OpenCitations bibliographic resource ID
2143714
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2143714
PMCID
4167745
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2143714
PubMed ID
25056119
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2143714
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