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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
scientific article
A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
23288408
retrieved
13 November 2016
title
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
(English)
1 reference
stated in
PubMed
PubMed ID
23288408
retrieved
13 November 2016
main subject
RNA interference
1 reference
based on heuristic
inferred from title
author
Jean-Philippe Theurillat
series ordinal
2
0 references
Dirk Schadendorf
series ordinal
7
0 references
Levi A Garraway
series ordinal
9
object named as
Levi A Garraway
0 references
David E Root
series ordinal
8
object named as
David E Root
0 references
Glenn S Cowley
series ordinal
6
object named as
Glenn S Cowley
0 references
author name string
Steven R Whittaker
series ordinal
1
0 references
Eliezer Van Allen
series ordinal
3
0 references
Nikhil Wagle
series ordinal
4
0 references
Jessica Hsiao
series ordinal
5
0 references
publication date
March 2013
0 references
published in
Cancer Discovery
1 reference
stated in
PubMed
volume
3
0 references
page(s)
350-62
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issue
3
0 references
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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
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MEK1 mutations confer resistance to MEK and B-RAF inhibition
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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
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29 September 2017
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.
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29 September 2017
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Nature and mRNA effect of 282 different NF1 point mutations: focus on splicing alterations
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23288408
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/2159-8290.CD-12-0470
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2038779
OpenCitations bibliographic resource ID
2038779
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2038779
PMCID
3606893
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2038779
PubMed ID
23288408
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2038779
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