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Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
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scholarly article
1 reference
stated in
PubMed
PubMed ID
26725216
retrieved
13 November 2016
title
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
(English)
1 reference
stated in
PubMed
PubMed ID
26725216
retrieved
13 November 2016
main subject
cell biology
0 references
pancreatic cancer
1 reference
based on heuristic
inferred from title
author
Krister Wennerberg
series ordinal
18
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Anirban Maitra
series ordinal
17
object named as
Anirban Maitra
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Channing Der
series ordinal
24
object named as
Channing J Der
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author name string
Tikvah K Hayes
series ordinal
1
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Nicole F Neel
series ordinal
2
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Chaoxin Hu
series ordinal
3
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Prson Gautam
series ordinal
4
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Melissa Chenard
series ordinal
5
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Brian Long
series ordinal
6
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Meraj Aziz
series ordinal
7
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Michelle Kassner
series ordinal
8
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Kirsten L Bryant
series ordinal
9
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Mariaelena Pierobon
series ordinal
10
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Raoud Marayati
series ordinal
11
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Swapnil Kher
series ordinal
12
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Samuel D George
series ordinal
13
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Mai Xu
series ordinal
14
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Andrea Wang-Gillam
series ordinal
15
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Ahmed A Samatar
series ordinal
16
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Emanuel F Petricoin
series ordinal
19
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Hongwei H Yin
series ordinal
20
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Barry Nelkin
series ordinal
21
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Adrienne D Cox
series ordinal
22
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Jen Jen Yeh
series ordinal
23
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publication date
11 January 2016
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published in
Cancer Cell
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volume
29
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page(s)
75-89
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issue
1
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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
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Targeting RAS-ERK signalling in cancer: promises and challenges
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RAS interaction with PI3K p110α is required for tumor-induced angiogenesis.
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Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
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Dragging ras back in the ring
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PubMed Central
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29 September 2017
MYC degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816652
retrieved
29 September 2017
KRAS: feeding pancreatic cancer proliferation
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PubMed Central
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Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance
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PubMed Central
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Tumor adaptation and resistance to RAF inhibitors
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ERK pathway inhibitors: how low should we go?
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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
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Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
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Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells
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29 September 2017
ERK inhibition overcomes acquired resistance to MEK inhibitors.
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Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer
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Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
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Pro-senescence therapy for cancer treatment
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Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
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Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer
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The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.
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Identifiers
DOI
10.1016/J.CCELL.2015.11.011
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
758322
OpenCitations bibliographic resource ID
758322
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
758322
PMCID
4816652
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
758322
PubMed ID
26725216
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
758322
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