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Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.
scientific article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
27321670
retrieved
1 December 2016
title
Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.
(English)
1 reference
stated in
PubMed
PubMed ID
27321670
retrieved
1 December 2016
main subject
E3 ubiquitin-protein ligase HRD1 YOL013C
1 reference
stated in
GOA release 2020-03-11
author
Tom Rapoport
series ordinal
2
object named as
Tom A Rapoport
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author name string
Ryan D Baldridge
series ordinal
1
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language of work or name
English
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publication date
14 July 2016
0 references
published in
Cell
1 reference
stated in
PubMed
PubMed ID
27321670
retrieved
1 December 2016
volume
166
0 references
page(s)
394-407
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issue
2
0 references
cites work
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PubMed Central
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20 March 2017
Key steps in ERAD of luminal ER proteins reconstituted with purified components
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20 March 2017
Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane
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20 March 2017
Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids
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PubMed Central
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20 March 2017
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
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PubMed Central
reference URL
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20 March 2017
Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
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20 March 2017
Sec61p is part of the endoplasmic reticulum-associated degradation machinery
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PubMed Central
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20 March 2017
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
1 reference
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PubMed Central
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20 March 2017
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
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PubMed Central
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20 March 2017
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation
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PubMed Central
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20 March 2017
TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum
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PubMed Central
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20 March 2017
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein
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PubMed Central
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20 March 2017
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
A membrane protein required for dislocation of misfolded proteins from the ER
1 reference
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PubMed Central
reference URL
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20 March 2017
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
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PubMed Central
reference URL
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20 March 2017
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
1 reference
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PubMed Central
reference URL
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20 March 2017
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation
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PubMed Central
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20 March 2017
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
Functional domains of the Rsp5 ubiquitin-protein ligase.
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PubMed Central
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20 March 2017
Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1 reference
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PubMed Central
reference URL
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20 March 2017
Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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20 March 2017
Cleaning up in the endoplasmic reticulum: ubiquitin in charge
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PubMed Central
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20 March 2017
Protein quality control at the inner nuclear membrane
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PubMed Central
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29 September 2017
Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD)
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Sortagging: a versatile method for protein labeling
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Protein translocation across biological membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulum
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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29 September 2017
The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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2 June 2018
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946995
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27 November 2018
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.
1 reference
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PubMed Central
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27 November 2018
The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for Its In Vitro Histone H2A Ligase Activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27321670
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27321670
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27321670
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2016.05.048
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3465155
OpenCitations bibliographic resource ID
3465155
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3465155
PMCID
4946995
0 references
PubMed ID
27321670
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3465155
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