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Engineering T Cells to Functionally Cure HIV-1 Infection
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review article
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Europe PubMed Central
title
Engineering T Cells to Functionally Cure HIV-1 Infection
(English)
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stated in
PubMed
author name string
Rachel S Leibman
series ordinal
1
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Crossref
James L Riley
series ordinal
2
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Crossref
language of work or name
English
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stated in
PubMed
publication date
July 2015
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stated in
PubMed
published in
Molecular Therapy
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stated in
PubMed
volume
23
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stated in
PubMed
issue
7
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PubMed
page(s)
1149-59
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PubMed
cites work
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Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
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29 September 2017
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment
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29 September 2017
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29 September 2017
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29 September 2017
HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo
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An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice
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Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection
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HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model
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Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha
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29 September 2017
Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance
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29 September 2017
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory act
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29 September 2017
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29 September 2017
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates
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29 September 2017
Downregulation of CCR5 expression on cells by recombinant adenovirus containing antisense CCR5, a possible measure to prevent HIV-1 from entering target cells
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29 September 2017
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
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29 September 2017
T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.
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29 September 2017
Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site
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29 September 2017
Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor
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29 September 2017
Aptamers directed to HIV-1 reverse transcriptase display greater efficacy over small hairpin RNAs targeted to viral RNA in blocking HIV-1 replication
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29 September 2017
T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120.
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29 September 2017
Protecting from R5-tropic HIV: individual and combined effectiveness of a hammerhead ribozyme and a single-chain Fv antibody that targets CCR5.
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29 September 2017
Lentiviral vectors: optimization of packaging, transduction and gene expression
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29 September 2017
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.
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29 September 2017
Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides
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29 September 2017
The nature of molecular recognition by T cells
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29 September 2017
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.
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29 September 2017
Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1.
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29 September 2017
Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference
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29 September 2017
Modulation of HIV-1 replication by RNA interference
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29 September 2017
Lentiviral transduction of human T-lymphocytes with a RANTES intrakine inhibits human immunodeficiency virus type 1 infection
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29 September 2017
siRNA-directed inhibition of HIV-1 infection
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29 September 2017
HIV preferentially infects HIV-specific CD4+ T cells
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29 September 2017
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
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29 September 2017
Approaches to gene therapy for human immunodeficiency virus infection
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29 September 2017
The dynamics of CD4+ T-cell depletion in HIV disease
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29 September 2017
Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.
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29 September 2017
Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
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29 September 2017
High level inhibition of HIV replication with combination RNA decoys expressed from an HIV-Tat inducible vector
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29 September 2017
Comparative analyses of intracellularly expressed antisense RNAs as inhibitors of human immunodeficiency virus type 1 replication
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29 September 2017
Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals
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29 September 2017
Inhibition of early and late events of the HIV-1 replication cycle by cytoplasmic Fab intrabodies against the matrix protein, p17
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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29 September 2017
Inhibition of recombinant human immunodeficiency virus type 1 replication by a site-specific recombinase
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29 September 2017
Change in coreceptor use correlates with disease progression in HIV-1--infected individuals
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29 September 2017
Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase.
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29 September 2017
Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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29 September 2017
Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients
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29 September 2017
Genotypic and phenotypic characterization of HIV-1 patients with primary infection
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29 September 2017
Zinc finger phage: affinity selection of fingers with new DNA-binding specificities
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29 September 2017
Length-encoded multiplex binding site determination: application to zinc finger proteins
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29 September 2017
A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat
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29 September 2017
Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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29 September 2017
Identification and analysis of antisense RNA target regions of the human immunodeficiency virus type 1.
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29 September 2017
Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation
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29 September 2017
A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity
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29 September 2017
In vitro effect of antisense oligonucleotides on human immunodeficiency virus type 1 reverse transcription
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29 September 2017
CCR5 Gene Editing of Resting CD4(+) T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice
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2 June 2018
In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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2 June 2018
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
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2 June 2018
Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs.
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2 June 2018
Determinants of human immunodeficiency virus type 1 resistance to membrane-anchored gp41-derived peptides
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2 June 2018
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects
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2 June 2018
Intracellular susceptibility to ribozymes in a tethered substrate-ribozyme provirus model is not predicted by secondary structures of human immunodeficiency virus type 1 RNAs in vitro
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2 June 2018
HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus
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2 June 2018
A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1.
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2 June 2018
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication
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2 June 2018
Dual-target inhibition of HIV-1 in vitro by means of an adeno-associated virus antisense vector
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2 June 2018
Inhibition of human immunodeficiency virus-1 production resulting from transduction with a retrovirus containing an HIV-regulated diphtheria toxin A chain gene
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2 June 2018
The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes
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27 November 2018
CasOT: a genome-wide Cas9/gRNA off-target searching tool
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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27 November 2018
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
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27 November 2018
Resistance of mature T cells to oncogene transformation
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27 November 2018
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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27 November 2018
Gene silencing of HIV chemokine receptors using ribozymes and single-stranded antisense RNA.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
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27 November 2018
Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals
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27 November 2018
Is spatial distribution of the HIV-1-resistant CCR5Delta32 allele formed by ecological factors?
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27 November 2018
Directed evolution of human T-cell receptors with picomolar affinities by phage display.
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27 November 2018
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
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27 November 2018
Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.
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27 November 2018
Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection
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27 November 2018
A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.
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27 November 2018
Functional T cell reconstitution and human immunodeficiency virus-1-specific cell-mediated immunity during highly active antiretroviral therapy
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27 November 2018
Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome.
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27 November 2018
In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
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27 November 2018
A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.
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27 November 2018
Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients.
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27 November 2018
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.
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27 November 2018
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
retrieved
27 November 2018
Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
retrieved
27 November 2018
Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4817793
retrieved
27 November 2018
Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Allogeneic transplantation of CCR5-deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
T-cell receptor diversity prevents T-cell lymphoma development
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CARs Move To the Fast Lane.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
HIV-specific cytotoxic T lymphocytes in seropositive individuals
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25896251
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transfer of Autologous Gene-modified T Cells in HIV-infected Patients with Advanced Immunodeficiency and Drug-resistant Virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2015.70
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/MT.2015.70
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4880879
OpenCitations bibliographic resource ID
4880879
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4880879
PMC publication ID
4817793
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4880879
PubMed publication ID
25896251
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4880879
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