(Q28242536)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

0 references

5

1 reference

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4 January 2020

author name string

Leah Rider

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Alla Shatrova

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Edward P Feener

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Leslie Webb

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

language of work or name

English

0 references

publication date

28 August 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

4 January 2020

number of pages

12

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

30985-30996

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

Biology of the p21-activated kinases

4 January 2020

cites work

1 reference

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PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

21 January 2018

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p21-activated kinases in cancer

21 January 2018

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

21 January 2018

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

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The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

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Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

21 January 2018

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Distinct cellular effects and interactions of the Rho-family GTPase TC10.

21 January 2018

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Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

21 January 2018

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Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

21 January 2018

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

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Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

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Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

21 January 2018

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Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

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p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

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A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

1 reference

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The Akt proto-oncogene links Ras to Pak and cell survival signals

21 January 2018

1 reference

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Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

21 January 2018

1 reference

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Cell cycle-regulated phosphorylation of p21-activated kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells

21 January 2018

1 reference

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An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

21 January 2018

1 reference

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NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Temporal and spatial distribution of activated Pak1 in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Jak2 is essential for signaling through a variety of cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

The phagokinetic tracks of 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

SH2-Bbeta is a Rac-binding protein that regulates cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Rac1 mediates STAT3 activation by autocrine IL-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Transforming growth factor alpha and mouse models of human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

Jak2 is involved in c-Myc induction by Bcr-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701794200

21 January 2018

Identifiers

DOI

10.1074/JBC.M701794200

2 references

Consolidated OpenCitations Corpus – April 2017

3973873

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726028%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

3973873

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

3973873