(Q28364222)

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A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9 (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

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Roger M. Phillips

9

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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G A Choudry

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

P A Stewart

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

J A Double

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

M R Krul

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

B Naylor

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

G M Flannigan

6

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

T K Shah

7

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

J E Brown

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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1 October 2001

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Europe PubMed Central

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3 December 2019

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

85

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1137-1146

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

copyright license

Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

1 October 2001

1 reference

April 2022 Public Data File from Crossref

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0 references

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

20 March 2017

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

20 March 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

7 April 2017

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Measurement of dicumarol-sensitive NADPH: (menadione-cytochrome c) oxidoreductase activity results in an artifactual assay of DT-diaphorase in cell sonicates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary ca

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Intravesical therapy. A critical review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Mechanism(s) of bioreductive activation. The example of diaziquone (AZQ).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Intravesical therapy in the management of superficial transitional cell carcinoma of the bladder: the experience of the EORTC GU Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

29 September 2017

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Mechanism for the reductive activation of diaziquone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor)oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2375160

2 June 2018

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-front intravesical chemotherapy for low stage, low grade recurrent bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer: a further report with 7 years of follow up

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The autoxidation of the reduced forms of EO9

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioreductive agents, hypoxic cells and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different pH dependency of mitomycin C activity in monolayer and three-dimensional cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological and biochemical determinants of the antitumour activity of the indoloquinone EO9

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11710826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1054/BJOC.2001.2056

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Dimensions Publication ID

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release_nllx6bpdc5awnnzbzypp62xuv4

1 reference

https://api.fatcat.wiki/v0/release/nllx6bpdc5awnnzbzypp62xuv4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11710826%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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