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Mechanism of chemical activation of Nrf2
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title
Mechanism of chemical activation of Nrf2
(English)
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author
Yuesheng Zhang
object named as
Yuesheng Zhang
series ordinal
3
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author name string
Yun Li
series ordinal
1
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Joseph D Paonessa
series ordinal
2
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language of work or name
English
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publication date
2012
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published in
PLOS One
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volume
7
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issue
4
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page(s)
e35122
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copyright license
Creative Commons Attribution 4.0 International
start time
25 April 2012
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April 2022 Public Data File from Crossref
copyright status
copyrighted
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cites work
The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration
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19 March 2017
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
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19 March 2017
Mechanistic studies of the Nrf2-Keap1 signaling pathway
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PubMed Central
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19 March 2017
Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer
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19 March 2017
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
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PubMed Central
reference URL
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19 March 2017
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
1 reference
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PubMed Central
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A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway
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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
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19 March 2017
Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
1 reference
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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
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Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
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Dual roles of Nrf2 in cancer
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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
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Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
1 reference
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reference URL
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Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
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Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
2 references
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PubMed Central
reference URL
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29 September 2017
stated in
PubMed Central
reference URL
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Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers
1 reference
stated in
PubMed Central
reference URL
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29 September 2017
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
1 reference
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reference URL
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29 September 2017
Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
1 reference
stated in
PubMed Central
reference URL
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retrieved
29 September 2017
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter
1 reference
stated in
PubMed Central
reference URL
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retrieved
29 September 2017
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
29 September 2017
Subcellular localization and cytoplasmic complex status of endogenous Keap1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338841
retrieved
27 November 2018
Identifiers
DOI
10.1371/JOURNAL.PONE.0035122
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2175056
ADS bibcode
2012PLoSO...735122L
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OpenCitations bibliographic resource ID
2175056
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2175056
PMC publication ID
3338841
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2175056
PubMed publication ID
22558124
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2175056
ResearchGate publication ID
224899351
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