(Q28550367)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

7

1 reference

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8 March 2020

author name string

Yukiko Ihara

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Yuko Tomonoh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Masanobu Deshimaru

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Bo Zhang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Taku Uchida

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Atsushi Ishii

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

language of work or name

English

0 references

publication date

24 February 2016

1 reference

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8 March 2020

1 reference

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8 March 2020

volume

11

1 reference

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8 March 2020

issue

2

1 reference

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8 March 2020

page(s)

e0150095

1 reference

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Creative Commons Attribution 4.0 International

8 March 2020

copyright license

start time

24 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents

19 March 2017

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Functional analysis of novel KCNQ2 and KCNQ3 gene variants found in a large pedigree with benign familial neonatal convulsions (BFNC)

19 March 2017

1 reference

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NKCC1 transporter facilitates seizures in the developing brain

19 March 2017

1 reference

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A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation

19 March 2017

1 reference

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KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum

19 March 2017

1 reference

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Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels

19 March 2017

1 reference

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Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine

19 March 2017

1 reference

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Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability

19 March 2017

1 reference

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The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

19 March 2017

1 reference

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A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions

19 March 2017

1 reference

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Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

19 March 2017

1 reference

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KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

19 March 2017

1 reference

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A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

19 March 2017

1 reference

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A revised Racine's scale for PTZ-induced seizures in rats

19 March 2017

1 reference

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Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Mutant GABA(A) receptor subunits in genetic (idiopathic) epilepsy.

29 September 2017

1 reference

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Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Kv7.2 regulates the function of peripheral sensory neurons

29 September 2017

1 reference

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The kick-in system: a novel rapid knock-in strategy.

29 September 2017

1 reference

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Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice

29 September 2017

1 reference

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Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents

29 September 2017

1 reference

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29 September 2017

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How theories evolved concerning the mechanism of action of barbiturates

29 September 2017

1 reference

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The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

29 September 2017

1 reference

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Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier

29 September 2017

1 reference

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A KCNQ channel opener for experimental neonatal seizures and status epilepticus

29 September 2017

1 reference

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Development of spontaneous recurrent seizures after kainate-induced status epilepticus

29 September 2017

1 reference

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Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions.

29 September 2017

1 reference

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Nervous system KV7 disorders: breakdown of a subthreshold brake

29 September 2017

1 reference

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Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex

29 September 2017

1 reference

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Genetics of idiopathic epilepsies

29 September 2017

1 reference

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Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Genetic identifiers of epilepsy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Neuronal KCNQ potassium channels: physiology and role in disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Ion channels and epilepsy in man and mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Retigabine (ezogabine) as add-on therapy for partial-onset seizures: an update for clinicians

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

KCNQ2 encephalopathy: emerging phenotype of a neonatal epileptic encephalopathy.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Dysfunction of M-channel enhances propagation of neuronal excitability in rat hippocampus monitored by multielectrode dish and microdialysis systems.

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Clinical spectrum of early onset epileptic encephalopathies caused by KCNQ2 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Neonatal convulsions and epileptic encephalopathy in an Italian family with a missense mutation in the fifth transmembrane region of KCNQ2

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Deletions involving both KCNQ2 and CHRNA4 present with benign familial neonatal seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Diuretic soothes seizures in newborns

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Identification of a residue in the γ-aminobutyric acid type A receptor α subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Developmental changes in KCNQ2 and KCNQ3 expression in human brain: possible contribution to the age-dependent etiology of benign familial neonatal convulsions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Age-dependent modulation of hippocampal excitability by KCNQ-channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Blue-gray mucocutaneous discoloration: a new adverse effect of ezogabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Temperature and pharmacological rescue of a folding-defective, dominant-negative KV 7.2 mutation associated with neonatal seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150095

Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

Developmental expression of GABA(A) receptor subunit mRNAs in individual hippocampal neurons in vitro and in vivo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4766199

KCNQ2 abnormality in BECTS: benign childhood epilepsy with centrotemporal spikes following benign neonatal seizures resulting from a mutation of KCNQ2

27 November 2018

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

NBQX blocks acute and late epileptogenic effects of perinatal hypoxia

1 reference

PubMed

12 December 2020

Retigabine: blue skin discoloration and retinal pigment abnormalities

1 reference

PubMed

12 December 2020

10.1371/JOURNAL.PONE.0150095

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

ADS bibcode

2016PLoSO..1150095I

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

26910900

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26910900%20AND%20SRC:MED&resulttype=core&format=json