(Q28550576)

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants (English)

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12

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14

object named as

Len Neckers

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13

object named as

Jane B Trepel

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Bradley T Scroggins

11

object named as

Bradley T Scroggins

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author name string

Thomas L Prince

1

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Toshiki Kijima

2

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Manabu Tatokoro

3

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Sunmin Lee

4

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Shinji Tsutsumi

5

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Kendrick Yim

6

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Candy Rivas

7

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Sylvia Alarcon

8

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Harvey Schwartz

9

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Kofi Khamit-Kush

10

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publication date

2015

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10

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10

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e0141786

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copyright license

Creative Commons CC0 License

30 October 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Regulation and function of the human HSP90AA1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Approaches for defining the Hsp90-dependent proteome

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

High-throughput mapping of a dynamic signaling network in mammalian cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Transcriptional and translational analysis of the murine 84- and 86-kDa heat shock proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

19 March 2017

Structure and mechanism of the Hsp90 molecular chaperone machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

7 April 2017

Role of the Keap1-Nrf2 pathway in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Designed Hsp90 heterodimers reveal an asymmetric ATPase-driven mechanism in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Solubility-promoting function of Hsp90 contributes to client maturation and robust cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Hsp90 molecular chaperone inhibitors: are we there yet?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Structure of an Hsp90-Cdc37-Cdk4 complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

29 September 2017

Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627809

3 June 2018

Modulation of Hsf1 activity by novobiocin and geldanamycin.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Exogenous expression of heat shock protein 90kDa retards the cell cycle and impairs the heat shock response

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Protein phosphatase 5 is a negative modulator of heat shock factor 1.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Structural and functional differences of cytosolic 90-kDa heat-shock proteins (Hsp90s) in Arabidopsis thaliana

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0141786

21 January 2018

Herbicidal effects of geldanamycin and nigericin, antibiotics from Streptomyces hygroscopicus

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https://pubmed.ncbi.nlm.nih.gov/26517842

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/26517842

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol

1 reference

https://pubmed.ncbi.nlm.nih.gov/26517842

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0141786

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2015PLoSO..1041786P

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