(Q28579310)

31 January 2017

title

Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation (English)

1 reference

31 January 2017

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Piero Marchetti

6

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Chantal Mathieu

8

object named as

Chantal Mathieu

1 reference

31 January 2017

5

Daniel J. Drucker

1 reference

31 January 2017

Conny Gysemans

7

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author name string

Jenny Barthson

1

1 reference

31 January 2017

Carla M. Germano

2

1 reference

31 January 2017

Fabrice Moore

3

1 reference

31 January 2017

Adriano Maida

4

1 reference

31 January 2017

Gabriel Nuñez

9

1 reference

31 January 2017

Andrea Jurisicova

10

1 reference

31 January 2017

Decio L. Eizirik

11

1 reference

31 January 2017

Esteban N. Gurzov

12

1 reference

31 January 2017

language of work or name

English

0 references

publication date

11 November 2011

1 reference

Journal of Biological Chemistry

31 January 2017

published in

1 reference

31 January 2017

volume

286

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31 January 2017

issue

45

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31 January 2017

page(s)

39632–39643

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STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation

31 January 2017

cites work

1 reference

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Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

17 March 2017

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p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

17 March 2017

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17 March 2017

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

17 March 2017

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ER stress triggers apoptosis by activating BH3-only protein Bim

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Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

29 September 2017

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29 September 2017

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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

29 September 2017

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29 September 2017

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PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

29 September 2017

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29 September 2017

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29 September 2017

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IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

29 September 2017

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29 September 2017

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Evidence based selection of housekeeping genes

29 September 2017

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Cisplatin and TNF-alpha downregulate transcription of Bcl-xL in murine malignant mesothelioma cells

29 September 2017

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

29 September 2017

1 reference

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Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

29 September 2017

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A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

29 September 2017

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IL-1 produced and released endogenously within human islets inhibits beta cell function

29 September 2017

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Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

29 September 2017

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29 September 2017

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

3 June 2018

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Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

21 January 2018

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The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice

21 January 2018

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IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

21 January 2018

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Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha

21 January 2018

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Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.

21 January 2018

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Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells

21 January 2018

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Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic -Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice

21 January 2018

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12 December 2020

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

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12 December 2020

A new in vitro model for the study of pancreatic A and B cells

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12 December 2020

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

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12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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12 December 2020

Upgrading the BCL-2 network

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12 December 2020

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection

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12 December 2020