(Q30244058)

12 June 2017

2 references

23 October 2022

Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry (English)

1 reference

12 June 2017

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Etienne Decroly

4

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Thomas Hoenen

object named as

Thomas Hoenen

series ordinal

2

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Bruno Canard

series ordinal

3

object named as

Bruno Canard

1 reference

12 June 2017

Baptiste Martin

1

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12 June 2017

publication date

14 September 2016

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12 June 2017

1 November 2016

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23 October 2022

2 references

12 June 2017

23 October 2022

135

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12 June 2017

page(s)

1-14

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Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection

12 June 2017

cites work

1 reference

12 December 2020

A Synthetic Serine Protease Inhibitor, Nafamostat Mesilate, Is a Drug Potentially Applicable to the Treatment of Ebola Virus Disease

1 reference

12 December 2020

Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry

1 reference

12 December 2020

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

1 reference

12 December 2020

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

1 reference

12 December 2020

Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models

1 reference

12 December 2020

Intracellular events and cell fate in filovirus infection

1 reference

12 December 2020

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

1 reference

12 December 2020

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

1 reference

12 December 2020

The anti-HIV-1 activity of chloroquine

1 reference

12 December 2020

Shedding of Ebola Virus Surface Glycoprotein Is a Mechanism of Self-regulation of Cellular Cytotoxicity and Has a Direct Effect on Virus Infectivity

1 reference

12 December 2020

On the etiology of an unknown human infection originating from monkeys

1 reference

12 December 2020

Association of the caveola vesicular system with cellular entry by filoviruses

1 reference

12 December 2020

Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells

1 reference

12 December 2020

Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein

1 reference

12 December 2020

RNA Editing of the GP Gene of Ebola Virus is an Important Pathogenicity Factor.

1 reference

12 December 2020

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

1 reference

12 December 2020

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

1 reference

12 December 2020

The multiple roles of sGP in Ebola pathogenesis

1 reference

12 December 2020

Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses

1 reference

12 December 2020

A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans

1 reference

12 December 2020

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

1 reference

12 December 2020

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

1 reference

12 December 2020

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

1 reference

12 December 2020

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

1 reference

12 December 2020

sGP serves as a structural protein in Ebola virus infection

1 reference

12 December 2020

Proteolytic processing of Marburg virus glycoprotein

1 reference

12 December 2020

Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure

1 reference

12 December 2020

Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses

1 reference

12 December 2020

Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function

1 reference

12 December 2020

Discovery of an ebolavirus-like filovirus in europe

1 reference

12 December 2020

Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection

1 reference

12 December 2020

Cathepsin B & L are not required for ebola virus replication

1 reference

12 December 2020

Ebolavirus and Marburgvirus: insight the Filoviridae family

1 reference

12 December 2020

Enzyme-linked immunosorbent assay for detection of filovirus species-specific antibodies

1 reference

12 December 2020

Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner

1 reference

12 December 2020

An Improved Reverse Genetics System to Overcome Cell-Type-Dependent Ebola Virus Genome Plasticity

1 reference

12 December 2020

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

1 reference

12 December 2020

Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb

1 reference

12 December 2020

The pathogenesis of Ebola hemorrhagic fever

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12 December 2020

Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection

1 reference

12 December 2020

Filovirus tropism: cellular molecules for viral entry

1 reference

12 December 2020

Structural and Functional Studies on the Marburg Virus GP2 Fusion Loop

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12 December 2020

Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence

1 reference

12 December 2020

Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus.

1 reference

12 December 2020

Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay

1 reference

12 December 2020

Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model

1 reference

12 December 2020

Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry

1 reference

12 December 2020

Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR

1 reference

12 December 2020

Filoviral immune evasion mechanisms

1 reference

12 December 2020

mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms

1 reference

12 December 2020

Ebola virus glycoprotein-mediated anoikis of primary human cardiac microvascular endothelial cells

1 reference

12 December 2020

C-peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: effects of conjugation to cholesterol and side chain-side chain crosslinking

1 reference

12 December 2020

Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding.

1 reference

12 December 2020

Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.

1 reference

12 December 2020

Epitopes required for antibody-dependent enhancement of Ebola virus infection

1 reference

12 December 2020

Ebola virus entry into host cells: identifying therapeutic strategies

1 reference

12 December 2020

Shed GP of Ebola virus triggers immune activation and increased vascular permeability

1 reference

12 December 2020

Filovirus assembly and budding

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12 December 2020

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

1 reference

12 December 2020

Analysis of the interaction of Ebola virus glycoprotein with DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) and its homologue DC-SIGNR.

1 reference

12 December 2020

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

1 reference

12 December 2020

Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies

1 reference

12 December 2020

Filovirus replication and transcription

1 reference

12 December 2020

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe

1 reference

12 December 2020

A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

1 reference

12 December 2020

Filoviruses utilize glycosaminoglycans for their attachment to target cells

1 reference

12 December 2020

Bidentate and tridentate metal-ion coordination states within ternary complexes of RB69 DNA polymerase

1 reference

12 December 2020

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents

1 reference

12 December 2020

LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus

1 reference

12 December 2020

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

1 reference

12 December 2020

Structural basis for Marburg virus neutralization by a cross-reactive human antibody

1 reference

12 December 2020

Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity

1 reference

12 December 2020

High-dose mannose-binding lectin therapy for Ebola virus infection

1 reference

12 December 2020

DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus

1 reference

12 December 2020

The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus

1 reference

12 December 2020

Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions

1 reference

12 December 2020

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

1 reference

12 December 2020

C-type lectins do not act as functional receptors for filovirus entry into cells

1 reference

12 December 2020

Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus

1 reference

12 December 2020

Emerging targets and novel approaches to Ebola virus prophylaxis and treatment

1 reference

12 December 2020

Structure-function analysis of the soluble glycoprotein, sGP, of Ebola virus.

1 reference

12 December 2020

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1.

1 reference

12 December 2020

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

1 reference

12 December 2020

Ebola virus uses clathrin-mediated endocytosis as an entry pathway

1 reference

12 December 2020

Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry.

1 reference

12 December 2020

Identification of a small-molecule entry inhibitor for filoviruses

1 reference

12 December 2020

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

1 reference

12 December 2020

Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry.

1 reference

12 December 2020

Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses

1 reference

12 December 2020

The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus

1 reference

12 December 2020

Phosphatidylserine receptors: enhancers of enveloped virus entry and infection

1 reference

12 December 2020

Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry

1 reference

12 December 2020

Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change

1 reference

12 December 2020

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

1 reference

12 December 2020

A broad-spectrum antiviral targeting entry of enveloped viruses

1 reference

12 December 2020

Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection

1 reference

12 December 2020

Different potential of C-type lectin-mediated entry between Marburg virus strains

1 reference

12 December 2020

Release of cellular proteases into the acidic extracellular milieu exacerbates Ebola virus-induced cell damage.

1 reference

12 December 2020

Protease inhibitors targeting coronavirus and filovirus entry

1 reference

12 December 2020

Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs.

1 reference

12 December 2020

Ebola haemorrhagic fever

1 reference

12 December 2020

Tyro3 family-mediated cell entry of Ebola and Marburg viruses

1 reference

12 December 2020

Novel Small Molecule Entry Inhibitors of Ebola Virus.

1 reference

12 December 2020

Antibody-dependent enhancement of Marburg virus infection

1 reference

12 December 2020

Soluble Glycoprotein Is Not Required for Ebola Virus Virulence in Guinea Pigs

1 reference

12 December 2020

Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease

1 reference

12 December 2020

Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice

1 reference

12 December 2020

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

1 reference

12 December 2020

Ectodomain shedding of the glycoprotein GP of Ebola virus

1 reference

12 December 2020

Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein

1 reference

12 December 2020

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry

1 reference

12 December 2020

The Role of histidine residues in low-pH-mediated viral membrane fusion

1 reference

12 December 2020

GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases

1 reference

12 December 2020

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

1 reference

12 December 2020

Assembly and budding of Ebolavirus

1 reference

12 December 2020

Less is more: Ebola virus surface glycoprotein expression levels regulate virus production and infectivity

1 reference

12 December 2020

Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations

1 reference

12 December 2020

Lack of protection against ebola virus from chloroquine in mice and hamsters

1 reference

12 December 2020

A new player in the puzzle of filovirus entry

1 reference

12 December 2020

Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger

1 reference

12 December 2020

A shared structural solution for neutralizing ebolaviruses

1 reference

12 December 2020

Characterization of Marburg virus glycoprotein in viral entry.

1 reference

12 December 2020

Modeling of the Ebola virus delta peptide reveals a potential lytic sequence motif

1 reference

12 December 2020

Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes

1 reference

12 December 2020

Antibody therapeutics for Ebola virus disease

1 reference

12 December 2020

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

1 reference

12 December 2020

DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

1 reference

12 December 2020

The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.

1 reference

12 December 2020

Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies

1 reference

12 December 2020

Antibody-dependent enhancement of Ebola virus infection

1 reference

12 December 2020

Characterization of the envelope glycoprotein of a novel filovirus, lloviu virus

1 reference

12 December 2020

Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins

1 reference

12 December 2020

The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis

1 reference

12 December 2020

The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing

1 reference

12 December 2020

A new Ebola virus nonstructural glycoprotein expressed through RNA editing

1 reference

12 December 2020

Ebolavirosis: a 2014 review for clinicians.

1 reference

12 December 2020

Teicoplanin inhibits Ebola pseudovirus infection in cell culture

1 reference

12 December 2020

Chloroquine could be used for the treatment of filoviral infections and other viral infections that emerge or emerged from viruses requiring an acidic pH for infectivity

1 reference

12 December 2020

FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

1 reference

12 December 2020

Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library.

1 reference

12 December 2020

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

1 reference

12 December 2020

Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with Similar Potency: Potential Therapeutic Implications

1 reference

12 December 2020

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

1 reference

12 December 2020

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

1 reference

12 December 2020

The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses

1 reference

12 December 2020

Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists

1 reference

12 December 2020

TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope

1 reference

12 December 2020

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein

1 reference

12 December 2020

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

1 reference

12 December 2020

Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus

1 reference

12 December 2020

1 reference

12 December 2020

Ebolavirus glycoprotein structure and mechanism of entry

1 reference

12 December 2020

Effects of chloroquine on viral infections: an old drug against today's diseases?

1 reference

12 December 2020

Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity

1 reference

12 December 2020

Chemical and Structural Aspects of Ebola Virus Entry Inhibitors

1 reference

12 December 2020

Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis

1 reference

12 December 2020

Lipids in innate antiviral defense

1 reference

12 December 2020

The Roles of Histidines and Charged Residues as Potential Triggers of a Conformational Change in the Fusion Loop of Ebola Virus Glycoprotein

1 reference

12 December 2020

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

1 reference

12 December 2020

Delta-peptide is the carboxy-terminal cleavage fragment of the nonstructural small glycoprotein sGP of Ebola virus

1 reference

12 December 2020

1 reference

12 December 2020

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans

1 reference

12 December 2020

Ebolavirus glycoprotein GP masks both its own epitopes and the presence of cellular surface proteins.

1 reference

12 December 2020

Progression of Ebola Therapeutics During the 2014-2015 Outbreak

1 reference

12 December 2020

10.1016/J.ANTIVIRAL.2016.09.001

Identifiers

DOI

1 reference

12 June 2017

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