(Q30453068)

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Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action

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scholarly article

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Europe PubMed Central

PMC publication ID

13 September 2017

Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

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object named as

Yves Pommier

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Europe PubMed Central

13 September 2017

PMC publication ID

2

object named as

John L Nitiss

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

author name string

Dirk Strumberg

1

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Europe PubMed Central

PMC publication ID

13 September 2017

Jiaowang Dong

3

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Europe PubMed Central

PMC publication ID

13 September 2017

Jerrylaine Walker

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Marc C Nicklaus

5

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Europe PubMed Central

PMC publication ID

13 September 2017

Kurt W Kohn

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Jonathan G Heddle

7

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Anthony Maxwell

8

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Europe PubMed Central

PMC publication ID

13 September 2017

Siegfried Seeber

9

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Europe PubMed Central

PMC publication ID

13 September 2017

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publication date

1 September 2002

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Europe PubMed Central

PMC publication ID

13 September 2017

number of pages

12

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Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

13 September 2017

46

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

2735-2746

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC127396/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

DNA topoisomerases: structure, function, and mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

DNA gyrase as a drug target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Structural similarities between topoisomerases that cleave one or both DNA strands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Topoisomerase IV catalysis and the mechanism of quinolone action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Use of a rapid throughput in vivo screen to investigate inhibitors of eukaryotic topoisomerase II enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Type II DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Crystal structure of the breakage-reunion domain of DNA gyrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

acrB mutation located at carboxyl-terminal region of gyrase B subunit reduces DNA binding of DNA gyrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

In the presence of subunit A inhibitors DNA gyrase cleaves DNA fragments as short as 20 bp at specific sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Characterization of topoisomerase II-DNA interaction and identification of a DNA-binding domain by ultraviolet laser crosslinking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Structure and mechanism of DNA topoisomerase II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Drug resistance associated with altered DNA topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Evidence for a conformational change in the DNA gyrase-DNA complex from hydroxyl radical footprinting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

DNA topoisomerases: essential enzymes and lethal targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

The mechanisms of DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Structure and function of DNA-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

The interaction of Escherichia coli topoisomerase IV with DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Site-specific interaction of DNA gyrase with DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Quinolone-resistant mutations of the gyrA gene of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Nuclease protection by Drosophila DNA topoisomerase II. Enzyme/DNA contacts at the strong topoisomerase II cleavage sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

A structural taxonomy of DNA-binding domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

The molecular basis of quinolone action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

A topoisomerase from Escherichia coli related to DNA gyrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

20 June 2018

Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

26 November 2018

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

26 November 2018

Role of the divalent cation in topoisomerase II mediated reactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

26 November 2018

Tryptic fragments of the Escherichia coli DNA gyrase A protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127396

26 November 2018

Footprinting of yeast DNA topoisomerase II lysyl side chains involved in substrate binding and interdomainal interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DNA Gyrase-Quinolone Complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical applications of quinolones

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic inhibitors of DNA topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in yeast topoisomerase II that confers hypersensitivity to multiple classes of topoisomerase II poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping the active site tyrosine of Escherichia coli DNA gyrase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12183223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.46.9.2735-2746.2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

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