(Q30528488)

14 August 2017

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung (English)

1 reference

14 August 2017

2

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Alexander Zarbock

9

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Arne Ittner

object named as

Arne Ittner

1

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Romeo Ricci

object named as

Romeo Ricci

10

0 references

Markku Varjosalo

object named as

Markku Varjosalo

4

0 references

author name string

Christoph A Reichel

3

1 reference

14 August 2017

Helmuth Gehart

5

1 reference

14 August 2017

Grzegorz Sumara

6

1 reference

14 August 2017

Matthias Gstaiger

7

1 reference

14 August 2017

Fritz Krombach

8

1 reference

14 August 2017

language of work or name

English

0 references

publication date

5 November 2012

1 reference

Journal of Experimental Medicine

14 August 2017

1 reference

14 August 2017

209

1 reference

14 August 2017

12

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14 August 2017

2229-2246

1 reference

describes a project that uses

14 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3501357/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.

20 June 2018

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The neutrophil in vascular inflammation

20 June 2018

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Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

20 June 2018

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Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling

20 June 2018

1 reference

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Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia

20 June 2018

1 reference

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Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

20 June 2018

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Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

20 June 2018

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Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

20 June 2018

1 reference

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p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

20 June 2018

1 reference

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Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like

20 June 2018

1 reference

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Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Large-scale proteomics analysis of the human kinome

20 June 2018

1 reference

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Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

20 June 2018

1 reference

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Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Understanding PTEN regulation: PIP2, polarity and protein stability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Origin and physiological roles of inflammation

20 June 2018

1 reference

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Protein kinase D1: a new component in TLR9 signaling

20 June 2018

1 reference

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Animal models of acute lung injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Moving towards a better understanding of chemotaxis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Requirement of protein kinase D1 for pathological cardiac remodeling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Galphai2 is required for chemokine-induced neutrophil arrest

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Protein kinase D1: a protein of emerging translational interest

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Neutrophils and immunity: challenges and opportunities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Pharmacological therapy for acute respiratory distress syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

20 June 2018

Dampening inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Regulation of PTEN by Rho small GTPases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

The role of endothelial PI3Kgamma activity in neutrophil trafficking

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

MAP kinases and cell migration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

The phosphoinositide 3-kinase pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

New responsibilities for the PI3K regulatory subunit p85 alpha.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Synthesis and function of 3-phosphorylated inositol lipids

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Chemokines: immunology's high impact factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

The acute respiratory distress syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

The multiple roles of PTEN in tumor suppression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Probability-based protein identification by searching sequence databases using mass spectrometry data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

20 June 2018

Phosphoinositide kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501357

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

20 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Selective role of PI3K delta in neutrophil inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Reproducible isolation of distinct, overlapping segments of the phosphoproteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120677

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23129748

12 December 2020

inferred from PubMed ID database lookup

L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23129748

12 December 2020

inferred from PubMed ID database lookup

Visualization of Leukocyte Transendothelial and Interstitial Migration Using Reflected Light Oblique Transillumination in Intravital Video Microscopy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23129748

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1084/JEM.20120677

1 reference

14 August 2017

1 reference

14 August 2017

1 reference