(Q30557542)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Epigenetic signature and enhancer activity of the human APOE gene (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Chang-En Yu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Eiron Cudaback

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Jessica Foraker

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Zachary Thomson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Lesley Leong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Franziska Lutz

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

James Anthony Gill

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Aleen Saxton

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Brian Kraemer

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Patrick Navas

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Lynn M Bekris

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

publication date

25 July 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

page(s)

5036-5047

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation

6 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Conserved role of intragenic DNA methylation in regulating alternative promoters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Intergenic, gene terminal, and intragenic CpG islands in the human genome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Human DNA methylomes at base resolution show widespread epigenomic differences

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E receptors in the nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

On the nature of human housekeeping genes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Screening reveals conserved and nonconserved transcriptional regulatory elements including an E3/E4 allele-dependent APOE coding region enhancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Age-specific epigenetic drift in late-onset Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Epigenetics: differential DNA methylation in mammalian somatic tissues

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Role of transposable elements in heterochromatin and epigenetic control

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Small babies receive the cardiovascular protective apolipoprotein epsilon 2 allele less frequently than expected

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Initial sequencing and analysis of the human genome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Genetic risk of Alzheimer's disease: advising relatives.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E and cognitive performance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Identification and characterization of a family of mammalian methyl-CpG binding proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

CpG islands in vertebrate genomes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

CpG-rich islands and the function of DNA methylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury

20 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Polymorphisms associated with cholesterol and risk of cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

Mixed-Effects Models in Sand S-PLUS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT354

DNA-binding factors shape the mouse methylome at distal regulatory regions

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

Identification of a novel enhancer of brain expression near the apoE gene cluster by comparative genomics

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836480

26 November 2018

1 reference

12 December 2020

Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter

1 reference

12 December 2020

Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemia

1 reference

12 December 2020

Human apolipoprotein E. The complete amino acid sequence

1 reference

12 December 2020

Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E

1 reference

12 December 2020

A methylated CpG island 3' in the apolipoprotein-E gene does not repress its transcription

1 reference

12 December 2020

Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men

1 reference

12 December 2020

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDT354

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892237%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

23892237

1 reference