(Q30781595)

26 June 2017

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells (English)

1 reference

26 June 2017

1 reference

Zhen Y Jiang

1

1 reference

26 June 2017

Qiong L Zhou

2

1 reference

26 June 2017

John Holik

3

1 reference

26 June 2017

Shraddha Patel

4

1 reference

26 June 2017

John Leszyk

5

1 reference

26 June 2017

Kerri Coleman

6

1 reference

26 June 2017

My Chouinard

7

1 reference

26 June 2017

Michael P Czech

8

1 reference

26 June 2017

language of work or name

English

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publication date

30 March 2005

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Journal of Biological Chemistry

26 June 2017

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26 June 2017

280

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26 June 2017

21622-21628

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26 June 2017

22

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

26 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Role of Akt/protein kinase B in metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Human hypertension caused by mutations in WNK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Analysis of insulin signalling by RNAi-based gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414464200

21 January 2018

Identifiers

DOI

10.1074/JBC.M414464200

1 reference

release_xdvhdnfionfirox4nmyflis6de

26 June 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xdvhdnfionfirox4nmyflis6de

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference