(Q31067372)

28 June 2017

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title

Cellular functions of gamma-secretase-related proteins (English)

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28 June 2017

2

Christian Haass

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author name string

Christof Haffner

series ordinal

1

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28 June 2017

1 January 2006

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Neurodegenerative Diseases

28 June 2017

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28 June 2017

3

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28 June 2017

4-5

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28 June 2017

284-289

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

28 June 2017

1 reference

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Identification of a novel family of presenilin homologues

21 January 2018

1 reference

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

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Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

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Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

21 January 2018

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Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

21 January 2018

1 reference

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

21 January 2018

1 reference

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

21 January 2018

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The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

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gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities.

21 January 2018

1 reference

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

21 January 2018

1 reference

Nodal Signaling in Vertebrate Development

21 January 2018

1 reference

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000095268

1 reference

28 June 2017

1 reference

PubMed ID

17047369