(Q33317126)

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Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

7

object named as

Ohyun Kwon

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

author name string

Masaru Watanabe

1

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Hannah D G Fiji

2

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Lea Guo

3

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Lai Chan

4

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Sape S Kinderman

5

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Dennis J Slamon

6

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Fuyuhiko Tamanoi

8

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

language of work or name

0 references

publication date

28 January 2008

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

283

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

15

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

9571-9579

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Small-molecule inhibitors of protein geranylgeranyltransferase type I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Therapeutic intervention based on protein prenylation and associated modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Inhibitors of protein: geranylgeranyl transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Emerging role of RAB GTPases in cancer and human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Phosphine-catalyzed synthesis of 1,3-dioxan-4-ylidenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Structure of mammalian protein geranylgeranyltransferase type-I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Membrane targeting of Rab GTPases is influenced by the prenylation motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Genomic analysis of metastasis reveals an essential role for RhoC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Protein prenylation: more than just glue?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

21 June 2018

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706229200

21 January 2018

Ethanol upregulates the expression of p21 WAF1/CIP1 and prolongs G1 transition via a p53-independent pathway in human epithelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706229200

21 January 2018

An Expedient Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Highly Functionalized Tetrahydropyridines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706229200

21 January 2018

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442295

31 October 2018

Analysis of the stoichiometry of Rab protein prenylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18230616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farnesyltransferase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18230616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphine-catalyzed synthesis of 6-substituted 2-pyrones: manifestation of E/Z-isomerism in the zwitterionic intermediate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18230616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M706229200

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

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