(Q33514156)

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Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

James L. Hougland

object named as

James L Hougland

1

0 references

Carol A. Fierke

6

object named as

Carol A Fierke

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

author name string

Katherine A Hicks

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Heather L Hartman

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Rebekah A Kelly

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Terry J Watt

5

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

language of work or name

0 references

publication date

28 October 2009

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Journal of Molecular Biology

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

395

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

176-190

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Context-dependent substrate recognition by protein farnesyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Combinatorial modulation of protein prenylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Towards complete sets of farnesylated and geranylgeranylated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Refinement and prediction of protein prenylation motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein prenyltransferases: anchor size, pseudogenes and parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

ExPASy: The proteomics server for in-depth protein knowledge and analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein prenylation: a pivotal posttranslational process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Reaction path of protein farnesyltransferase at atomic resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Enzymology and biology of CaaX protein prenylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Investigation of S-farnesyl transferase substrate specificity with combinatorial tetrapeptide libraries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

High-level expression of rat farnesyl:protein transferase in Escherichia coli as a translationally coupled heterodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Characterization of RAC3, a novel member of the Rho family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein prenyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Lipid modifications of G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

p21ras is modified by a farnesyl isoprenoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Enzymatic modification of proteins with a geranylgeranyl isoprenoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Sequence dependence of protein isoprenylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Steady-state kinetic mechanism of Ras farnesyl:protein transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Protein prenylation: key to ras function and cancer intervention?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Post-translational modifications of p21rho proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid)—a reexamination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

21 June 2018

Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

A continuous fluorescent assay for protein prenyltransferases measuring diphosphate release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Small GTPase RhoD suppresses cell migration and cytokinesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916699

31 October 2018

Substrate binding is required for release of product from mammalian protein farnesyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein prenylation: a mediator of protein-protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New clue to Ras lipid glue

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous fluorescence assay for protein prenyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release

1 reference

https://pubmed.ncbi.nlm.nih.gov/19878682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2009.10.038

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

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