(Q33570056)

28 July 2017

title

Update: the status of clinical trials with kinase inhibitors in thyroid cancer (English)

1 reference

28 July 2017

1 reference

Samuel A Wells

1

1 reference

28 July 2017

Massimo Santoro

series ordinal

2

1 reference

28 July 2017

language of work or name

English

0 references

publication date

13 January 2014

1 reference

The Journal of Clinical Endocrinology and Metabolism

28 July 2017

published in

1 reference

28 July 2017

volume

99

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28 July 2017

issue

5

1 reference

28 July 2017

page(s)

1543-1555

1 reference

The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations

28 July 2017

cites work

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21 June 2018

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21 June 2018

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Utility of a PI3K/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy.

21 June 2018

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21 June 2018

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21 June 2018

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Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

21 June 2018

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21 June 2018

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

21 June 2018

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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

21 June 2018

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Imatinib enhances docetaxel-induced apoptosis through inhibition of nuclear factor-κB activation in anaplastic thyroid carcinoma cells

21 June 2018

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Intra-tumour heterogeneity: a looking glass for cancer?

21 June 2018

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Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer

21 June 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 June 2018

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21 June 2018

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Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements

21 June 2018

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Pharmacotherapy options for advanced thyroid cancer: a systematic review

21 June 2018

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The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma.

21 June 2018

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21 June 2018

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

21 June 2018

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Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro.

21 June 2018

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Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

21 June 2018

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The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAF(V600E) inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells

21 June 2018

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Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial

21 June 2018

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Emerging therapeutics for advanced thyroid malignancies: rationale and targeted approaches

21 June 2018

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21 June 2018

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Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer

21 June 2018

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Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer

21 June 2018

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Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

21 June 2018

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BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus.

21 June 2018

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Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies

21 June 2018

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21 June 2018

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

21 June 2018

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21 June 2018

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21 June 2018

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer

21 June 2018

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21 June 2018

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21 June 2018

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Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer

21 June 2018

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Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer.

21 June 2018

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Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

21 June 2018

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Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo

21 June 2018

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A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome

21 June 2018

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Phase II trial of sorafenib in metastatic thyroid cancer

21 June 2018

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Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005.

21 June 2018

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Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth

21 June 2018

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21 June 2018

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

21 June 2018

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Motesanib diphosphate in progressive differentiated thyroid cancer.

21 June 2018

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21 June 2018

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Phase II trial of sorafenib in advanced thyroid cancer

21 June 2018

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The Jeremiah Metzger Lecture: intelligent design of cancer therapy: trials and tribulations.

21 June 2018

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Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines

21 June 2018

1 reference

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

21 June 2018

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

21 June 2018

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Establishment and characterization of cell lines from three human thyroid carcinomas: responses to all-trans-retinoic acid and mutations in the BRAF gene

21 June 2018

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The multiple endocrine neoplasia syndromes

21 June 2018

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RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis

21 June 2018

1 reference

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Antitumor effects of the proteasome inhibitor bortezomib in medullary and anaplastic thyroid carcinoma cells in vitro

21 June 2018

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Genetic clonal diversity predicts progression to esophageal adenocarcinoma

21 June 2018

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Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches

21 June 2018

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Thyroid tumors: histological classification and genetic factors involved in the development of thyroid cancer

21 June 2018

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Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1.

21 June 2018

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21 June 2018

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21 June 2018

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

21 June 2018

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Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

21 June 2018

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Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation

21 June 2018

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

21 June 2018

1 reference

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Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors

21 June 2018

1 reference

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RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 June 2018

1 reference

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PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

21 June 2018

1 reference

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Gene rearrangement and Chernobyl related thyroid cancers

21 June 2018

1 reference

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Thyroid cancer: a lethal endocrine neoplasm

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Randomized safety and efficacy study of fosbretabulin with paclitaxel/carboplatin against anaplastic thyroid carcinoma.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

A new mode of RAF autoregulation: a further complication in the inhibitor paradox.

31 October 2018

1 reference

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Allele percentage of the BRAF V600E mutation in papillary thyroid carcinomas and corresponding lymph node metastases: no evidence for a role in tumor progression

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

BRAF V600E inhibition in anaplastic thyroid cancer.

31 October 2018

1 reference

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Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

A missing link in genotype-directed cancer therapy.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Translational medicine: Primed for resistance.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Combining nilotinib and imatinib improves the outcome of imatinib-resistant blast phase CML.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Evaluation of Aurora kinase inhibition as a new therapeutic strategy in anaplastic and poorly differentiated follicular thyroid cancer.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Tumorigenic and metastatic activity of human thyroid cancer stem cells.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

A phase II study of imatinib in patients with advanced anaplastic thyroid cancer

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Increasing incidence of differentiated thyroid cancer in the United States, 1988-2005.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

A phase II study of gefitinib in patients with advanced thyroid cancer.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Efficacy of imatinib mesylate in advanced medullary thyroid carcinoma.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393476

Increasing incidence of thyroid cancer in the United States, 1973-2002

31 October 2018

1 reference

12 December 2020

More about Imatinib and Nilotinib Combination Therapy in Chronic Myeloid Leukemia

1 reference

12 December 2020

Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer

1 reference

12 December 2020

Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations

1 reference

12 December 2020

Comments on "Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: the phase III DECISION trial"

1 reference

12 December 2020

Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial

1 reference

12 December 2020

A phase II trial of imatinib therapy for metastatic medullary thyroid carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1210/JC.2013-2622

1 reference

28 July 2017

1 reference

28 July 2017

1 reference