(Q33594040)

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Mdm2: the ups and downs

scientific article

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

Mdm2: the ups and downs (English)

1 reference

Europe PubMed Central

28 July 2017

author name string

T Juven-Gershon

1

1 reference

Europe PubMed Central

28 July 2017

M Oren

2

1 reference

Europe PubMed Central

28 July 2017

language of work or name

0 references

publication date

1 February 1999

1 reference

Europe PubMed Central

28 July 2017

Molecular Medicine

1 reference

Europe PubMed Central

28 July 2017

5

1 reference

Europe PubMed Central

28 July 2017

71-83

1 reference

Europe PubMed Central

28 July 2017

2

1 reference

Europe PubMed Central

28 July 2017

p53-independent role of MDM2 in TGF-beta1 resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

p14ARF links the tumour suppressors RB and p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The MDM2 gene amplification database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

MDM2 expression during mouse embryogenesis and the requirement of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Mdm2: keeping p53 under control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Repression of p53-mediated transcription by MDM2: a dual mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Molecular characterization of the hdm2-p53 interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Synergistic activation of transcription by CBP and p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Regulation of p53 stability by Mdm2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Mdm-2: "big brother" of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Identification of novel mdm2 binding peptides by phage display.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Functional interaction between DP-1 and p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Amplification of MDM2 inhibits MyoD-mediated myogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

mdm2 expression is induced by wild type p53 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Physical and functional interaction between wild-type p53 and mdm2 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The mdm-2 gene is induced in response to UV light in a p53-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Mapping of the p53 and mdm-2 interaction domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

21 June 2018

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

30 October 2018

High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

30 October 2018

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

30 October 2018

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

30 October 2018

MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

30 October 2018

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230410

30 October 2018

The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 Mutation and MDM2 amplification in human soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDM2 gene amplification in metastatic osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity cytotoxic T lymphocytes that recognize naturally processed protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10203572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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