(Q33619364)

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ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation (English)

1 reference

Europe PubMed Central

28 July 2017

transmembrane protein

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author name string

Tommy S Tillman

1

1 reference

Europe PubMed Central

28 July 2017

Edom Seyoum

2

1 reference

Europe PubMed Central

28 July 2017

David D Mowrey

3

1 reference

Europe PubMed Central

28 July 2017

Yan Xu

4

1 reference

Europe PubMed Central

28 July 2017

Pei Tang

5

1 reference

Europe PubMed Central

28 July 2017

language of work or name

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publication date

2 April 2014

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Europe PubMed Central

28 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

28 July 2017

289

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Europe PubMed Central

28 July 2017

20

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Europe PubMed Central

28 July 2017

13851-13857

1 reference

Europe PubMed Central

28 July 2017

NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites

1 reference

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21 June 2018

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

1 reference

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21 June 2018

Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography

1 reference

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21 June 2018

Gating of pentameric ligand-gated ion channels: structural insights and ambiguities

1 reference

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21 June 2018

Nicotinic acetylcholine receptors controlling attention: behavior, circuits and sensitivity to disruption by nicotine

1 reference

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21 June 2018

Nicotinic modulation of intrinsic brain networks in schizophrenia

1 reference

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21 June 2018

Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies

1 reference

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21 June 2018

Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors

1 reference

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21 June 2018

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

1 reference

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21 June 2018

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

1 reference

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21 June 2018

An outline of desensitization in pentameric ligand-gated ion channel receptors.

1 reference

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21 June 2018

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

1 reference

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21 June 2018

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

1 reference

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21 June 2018

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Synaptic neurotransmitter-gated receptors

1 reference

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21 June 2018

New insights into the structural bases of activation of Cys-loop receptors

1 reference

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21 June 2018

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation

1 reference

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21 June 2018

Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Principles of activation and permeation in an anion-selective Cys-loop receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

21 June 2018

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

1 reference

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21 June 2018

Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator

1 reference

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The gating isomerization of neuromuscular acetylcholine receptors

1 reference

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21 June 2018

An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine

1 reference

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21 June 2018

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

1 reference

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21 June 2018

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

1 reference

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21 June 2018

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

1 reference

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21 June 2018

Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment

1 reference

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21 June 2018

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization

1 reference

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Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

1 reference

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21 June 2018

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

1 reference

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Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis

1 reference

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Allosteric modulation of nicotinic acetylcholine receptors

1 reference

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Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

1 reference

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The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.

1 reference

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Recent advances in Cys-loop receptor structure and function

1 reference

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Molecular tuning of fast gating in pentameric ligand-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022858

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A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

1 reference

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

1 reference

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Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

1 reference

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Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

1 reference

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Modeling of loops in protein structures

1 reference

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Up-regulation of cell-surface alpha4beta2 neuronal nicotinic receptors by lower temperature and expression of chimeric subunits

1 reference

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Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

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A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1 reference

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Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice

1 reference

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Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera

1 reference

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21 January 2018

Mechanism of Allosteric Modulation of the Cys-loop Receptors

1 reference

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21 January 2018

Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities.

1 reference

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21 January 2018

Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected.

1 reference

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21 January 2018

Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M113.524611

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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