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Insights into cancer from transgenic mouse models
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Insights into cancer from transgenic mouse models
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
author name string
Macleod KF
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
Jacks T
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
language of work or name
English
1 reference
based on heuristic
inferred from title
publication date
1 January 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
published in
Journal of Pathology
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
volume
187
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
page(s)
43-60
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
cites work
Dissecting multistep tumorigenesis in transgenic mice
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Transgenic mice as probes into complex systems
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21 January 2018
Transgenic models of tumor development.
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21 January 2018
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
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21 January 2018
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
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21 January 2018
Antioncogenes and human cancer
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21 January 2018
Tumor suppressor gene mutations in mice
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21 January 2018
Effects of an Rb mutation in the mouse
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21 January 2018
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
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21 January 2018
Requirement for a functional Rb-1 gene in murine development
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21 January 2018
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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21 January 2018
Tumor spectrum analysis in p53-mutant mice
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21 January 2018
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
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21 January 2018
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
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21 January 2018
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
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21 January 2018
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
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21 January 2018
Role of the INK4a locus in tumor suppression and cell mortality.
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21 January 2018
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
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21 January 2018
Tumor suppressor mutations in mice: the next generation
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21 January 2018
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
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21 January 2018
The multistep nature of cancer
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21 January 2018
Lessons from hereditary colorectal cancer
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21 January 2018
A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
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21 January 2018
A causal role for E-cadherin in the transition from adenoma to carcinoma
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21 January 2018
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
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21 January 2018
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
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21 January 2018
Cadherins in cancer: implications for invasion and metastasis
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21 January 2018
E-cadherin germline mutations in familial gastric cancer.
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21 January 2018
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
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21 January 2018
Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia
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21 January 2018
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
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21 January 2018
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
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21 January 2018
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
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21 January 2018
Bovine papillomavirus genome elicits skin tumours in transgenic mice
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21 January 2018
Retinoblastoma in transgenic mice
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21 January 2018
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
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21 January 2018
Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.
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21 January 2018
Second primary neoplasms in patients with retinoblastoma
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21 January 2018
Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein
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21 January 2018
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
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21 January 2018
Mutations in the p53 gene occur in diverse human tumour types
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21 January 2018
p53 mutations in human cancers
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21 January 2018
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
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21 January 2018
Suppression of human colorectal carcinoma cell growth by wild-type p53
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Crossref
reference URL
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21 January 2018
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
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21 January 2018
p53 and the Li-Fraumeni syndrome
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21 January 2018
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
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21 January 2018
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
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Crossref
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21 January 2018
A novel protein with strong homology to the tumor suppressor p53.
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21 January 2018
p73 is a simian [correction of human] p53-related protein that can induce apoptosis
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21 January 2018
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
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21 January 2018
Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis
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21 January 2018
Cancer. p53, guardian of the genome
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21 January 2018
p53 is required for radiation-induced apoptosis in mouse thymocytes
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Crossref
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21 January 2018
Thymocyte apoptosis induced by p53-dependent and independent pathways.
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21 January 2018
Tissue-specific inactivation of p53 tumor suppression in the mouse.
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21 January 2018
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
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retrieved
21 January 2018
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
Regulation of p53 stability by Mdm2
1 reference
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Crossref
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retrieved
21 January 2018
Mdm2 promotes the rapid degradation of p53
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
p53 modulation of TFIIH-associated nucleotide excision repair activity
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
p53: puzzle and paradigm
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
p53, the cellular gatekeeper for growth and division
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
Identification of p53 as a sequence-specific DNA-binding protein
1 reference
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Crossref
reference URL
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retrieved
21 January 2018
Regulation of the specific DNA binding function of p53
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Crossref
reference URL
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21 January 2018
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
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Crossref
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21 January 2018
Presence of a potent transcription activating sequence in the p53 protein
1 reference
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Crossref
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21 January 2018
Wild-type p53 is a cell cycle checkpoint determinant following irradiation
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21 January 2018
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
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21 January 2018
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?
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21 January 2018
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21 January 2018
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21 January 2018
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21 January 2018
p21 is a universal inhibitor of cyclin kinases
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21 January 2018
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21 January 2018
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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21 January 2018
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.
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21 January 2018
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21 January 2018
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21 January 2018
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21 January 2018
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21 January 2018
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21 January 2018
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21 January 2018
A novel form of Epstein-Barr virus latency in normal B cells in vivo
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21 January 2018
Induction of the growth inhibitor IGF-binding protein 3 by p53
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21 January 2018
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21 January 2018
Bax suppresses tumorigenesis and stimulates apoptosis in vivo
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21 January 2018
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
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21 January 2018
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21 January 2018
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21 January 2018
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.
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21 January 2018
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
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21 January 2018
Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells
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21 January 2018
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
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21 January 2018
No requirement for V(D)J recombination in p53-deficient thymic lymphoma
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21 January 2018
Mutation and cancer: statistical study of retinoblastoma
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21 January 2018
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
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21 January 2018
Interaction of p53 with its consensus DNA-binding site
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21 January 2018
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential
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21 January 2018
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21 January 2018
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
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21 January 2018
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
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21 January 2018
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
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21 January 2018
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo
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21 January 2018
The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice
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21 January 2018
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21 January 2018
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.
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21 January 2018
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.
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21 January 2018
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21 January 2018
Induction of apoptosis in fibroblasts by c-myc protein
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21 January 2018
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
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21 January 2018
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21 January 2018
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells
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21 January 2018
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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21 January 2018
Inactivation of the retinoblastoma susceptibility gene in human breast cancers
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21 January 2018
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
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21 January 2018
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
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21 January 2018
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
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21 January 2018
Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene
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21 January 2018
Function of a human cyclin gene as an oncogene
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21 January 2018
CDC25 phosphatases as potential human oncogenes
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21 January 2018
Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53
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21 January 2018
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21 January 2018
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.
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21 January 2018
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
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21 January 2018
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
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21 January 2018
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
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21 January 2018
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
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21 January 2018
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
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21 January 2018
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21 January 2018
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
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21 January 2018
A novel cyclin encoded by a bcl1-linked candidate oncogene
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21 January 2018
The retinoblastoma protein and cell cycle control
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21 January 2018
Cyclin D1 provides a link between development and oncogenesis in the retina and breast.
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21 January 2018
Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.
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21 January 2018
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
1 reference
stated in
Crossref
reference URL
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21 January 2018
CDK-independent activation of estrogen receptor by cyclin D1
1 reference
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Crossref
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21 January 2018
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
1 reference
stated in
Crossref
reference URL
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21 January 2018
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1 reference
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Crossref
reference URL
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21 January 2018
Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.
1 reference
stated in
Crossref
reference URL
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21 January 2018
A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6.
1 reference
stated in
Crossref
reference URL
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21 January 2018
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
1 reference
stated in
Crossref
reference URL
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21 January 2018
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system
1 reference
stated in
Crossref
reference URL
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21 January 2018
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
1 reference
stated in
Crossref
reference URL
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21 January 2018
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
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21 January 2018
Site-specific recombinases: tools for genome engineering.
1 reference
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Crossref
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21 January 2018
Inducible gene targeting in mice
1 reference
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Crossref
reference URL
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21 January 2018
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
1 reference
stated in
Crossref
reference URL
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21 January 2018
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
1 reference
stated in
Crossref
reference URL
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21 January 2018
Inducible gene expression systems for higher eukaryotic cells
1 reference
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Crossref
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retrieved
21 January 2018
Ligand-activated site-specific recombination in mice
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
WT-1 is required for early kidney development
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
MSH2 deficient mice are viable and susceptible to lymphoid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
For our eyes only
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Sunburn and p53 in the onset of skin cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291096-9896%28199901%29187%3A1%3C43%3A%3AAID-PATH246%3E3.0.CO%3B2-P
retrieved
21 January 2018
Identifiers
DOI
10.1002/(SICI)1096-9896(199901)187:1<43::AID-PATH246>3.0.CO;2-P
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
PubMed ID
10341706
1 reference
stated in
Europe PubMed Central
PubMed ID
10341706
retrieved
28 July 2017
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