(Q33778362)

29 July 2017

title

Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain (English)

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29 July 2017

0 references

5

Gorm Danscher

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29 July 2017

3

Wei Zheng

1 reference

29 July 2017

Chun-Yan Wang

1

1 reference

29 July 2017

Tao Wang

2

1 reference

29 July 2017

Bao-Lu Zhao

4

1 reference

29 July 2017

Yu-Hua Chen

6

1 reference

29 July 2017

Zhan-You Wang

7

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29 July 2017

language of work or name

English

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publication date

17 December 2010

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29 July 2017

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29 July 2017

volume

5

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29 July 2017

issue

12

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29 July 2017

page(s)

e15349

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

17 December 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation

4 July 2018

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Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

4 July 2018

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Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

4 July 2018

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Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

4 July 2018

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Metals in Alzheimer's and Parkinson's diseases

4 July 2018

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Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide

4 July 2018

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Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells

4 July 2018

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Silver enhancement of quantum dots resulting from (1) metabolism of toxic metals in animals and humans, (2) in vivo, in vitro and immersion created zinc-sulphur/zinc-selenium nanocrystals, (3) metal ions liberated from metal implants and particles

4 July 2018

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Clioquinol for the treatment of Alzheimer's Disease

4 July 2018

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Protective effect of zinc on amyloid-beta 25-35 and 1-40 mediated toxicity.

4 July 2018

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Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease

4 July 2018

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Metals and amyloid-beta in Alzheimer's disease

4 July 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

4 July 2018

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

4 July 2018

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Modulation of mitochondrial function by endogenous Zn2+ pools.

4 July 2018

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Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration.

4 July 2018

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Metal complexing agents as therapies for Alzheimer's disease

4 July 2018

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

4 July 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

4 July 2018

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New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

4 July 2018

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

4 July 2018

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4 July 2018

Metals and neuroscience.

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Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

4 July 2018

1 reference

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

4 July 2018

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease.

4 July 2018

1 reference

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Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Copper, iron and zinc in Alzheimer's disease senile plaques

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Rapid induction of Alzheimer A beta amyloid formation by zinc.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

4 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Elevated zinc transporter-6 in mild cognitive impairment, Alzheimer disease, and pick disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Protection against amyloid beta peptide toxicity by zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Effects of cadmium, copper, and zinc and beta APP processing and turnover in COS-7 and PC12 cells. Relationship to Alzheimer disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Elevation of zinc transporter ZnT3 protein in the cerebellar cortex of the AbetaPP/PS1 transgenic mouse

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003690

Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex

30 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015349

Zinc as an ambivalent but potent modulator of murine hair growth in vivo- preliminary observations

21 January 2018

1 reference

12 December 2020

Oral zinc sulphate causes murine hair hypopigmentation and is a potent inhibitor of eumelanogenesis in vivo

1 reference

12 December 2020

Zinc Lowers Amyloid-β Toxicity by Selectively Precipitating Aggregation Intermediates†

1 reference

12 December 2020

Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

1 reference

12 December 2020

Zinc takes the center stage: its paradoxical role in Alzheimer's disease

1 reference

12 December 2020

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1 reference

12 December 2020

Prevention of zinc neurotoxicity in vivo by N,N,N',N'-tetrakis (2-pyridylmethyl) ethylene-diamine (TPEN)

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015349

Identifiers

DOI

1 reference

29 July 2017

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29 July 2017

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