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Zinc takes the center stage: its paradoxical role in Alzheimer's disease
scientific article published on 01 January 2003
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Zinc takes the center stage: its paradoxical role in Alzheimer's disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
main subject
Alzheimer's disease
1 reference
based on heuristic
inferred from title
author
Math P. Cuajungco
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
author name string
Kyle Y Fagét
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
publication date
1 January 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
volume
41
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
page(s)
44-56
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
cites work
Laminin interactions important for basement membrane assembly are promoted by zinc and implicate laminin zinc finger-like sequences
1 reference
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Crossref
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7 January 2021
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Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture
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7 January 2021
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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides
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7 January 2021
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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
1 reference
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Crossref
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7 January 2021
based on heuristic
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Hydrogen peroxide mediates amyloid beta protein toxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
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inferred from DOI database lookup
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
1 reference
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Crossref
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7 January 2021
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Alpha-2 macroglobulin is genetically associated with Alzheimer disease
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Crossref
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7 January 2021
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The physiological role of zinc as an antioxidant
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7 January 2021
based on heuristic
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Selective aggregation of endogenous beta-amyloid peptide and soluble amyloid precursor protein in cerebrospinal fluid by zinc.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
A possible role of zinc in the pathology of dementia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid induction of Alzheimer A beta amyloid formation by zinc.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc neurotoxicity in cortical cell culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hippocampal tin, aluminum and zinc in Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intramuscular desferrioxamine in patients with Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc and Alzheimer's Disease: An Update.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevention of zinc neurotoxicity in vivo by N,N,N',N'-tetrakis (2-pyridylmethyl) ethylene-diamine (TPEN)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc metabolism in the brain: relevance to human neurodegenerative disorders
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metal chelation as a potential therapy for Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Selective loss of central cholinergic neurons in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human memory and the cholinergic system. A relationship to aging?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonidentical distribution of transferrin and ferric iron in human brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc-induced aggregation of human and rat beta-amyloid peptides in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxygen toxicity, oxygen radicals, transition metals and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrogen peroxide. Ubiquitous in cell culture and in vivo?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The beta A4 amyloid precursor protein binding to copper.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synaptic beta-amyloid precursor proteins increase with learning capacity in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perforant pathway changes and the memory impairment of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of zinc in selective neuronal death after transient global cerebral ischemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A familial Alzheimer's disease locus on chromosome 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transition metal-mediated glycoxidation accelerates cross-linking of beta-amyloid peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protection against amyloid beta peptide toxicity by zinc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Copper, iron and zinc in Alzheimer's disease senile plaques
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Low dietary zinc alters indices of copper function and status in postmenopausal women
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Susceptibility locus for Alzheimer's disease on chromosome 10.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Trace elements in the human central nervous system studied with neutron activation analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antioxidant properties of zinc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of Alzheimer's disease with clioquinol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Redox-active iron mediates amyloid-beta toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum zinc levels and Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elemental imbalances in the olfactory pathway in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of iron in beta amyloid toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The distribution of beta-amyloid precursor protein in rat cortex after systemic kainate-induced seizures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Widespread peroxynitrite-mediated damage in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitory effect of copper(II) on zinc(II)-induced aggregation of amyloid beta-peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid beta protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum zinc, senile plaques, and neurofibrillary tangles: findings from the Nun Study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid beta-protein precursor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of hydrogen peroxide as a photoproduct toxic to human cells in tissue-culture medium irradiated with "daylight" fluorescent light
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Examining the zinc binding site of the amyloid-beta peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antioxidant properties of zinc: interactions with iron and antioxidants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fresh and nonfibrillar amyloid beta protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AbetaP-channel-mediated cellular toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2802%2900219-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-0173(02)00219-9
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
PubMed publication ID
12505647
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12505647
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12505647%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 December 2019
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