(Q33785941)

27843137

29 July 2017

title

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis (English)

1 reference

29 July 2017

1 reference

Stuart James Blakemore

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Francesco Forconi

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Graham Packham

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Mark S Cragg

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

M J Carter

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

K L Cox

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

A H Turaj

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

R J Oldham

5

1 reference

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5 June 2020

L N Dahal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

S Tannheimer

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

publication date

15 November 2016

1 reference

27843137

29 July 2017

number of pages

11

1 reference

based on heuristic

inferred from page(s)

published in

Leukemia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

6

1 reference

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5 June 2020

page(s)

1423-1433

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

5 June 2020

copyright license

start time

15 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/leu.2016.333

0 references

cites work

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4 July 2018

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FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas.

4 July 2018

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4 July 2018

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BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

4 July 2018

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Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice

4 July 2018

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MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

4 July 2018

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Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

4 July 2018

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4 July 2018

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Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

4 July 2018

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4 July 2018

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The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells

4 July 2018

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4 July 2018

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Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption

4 July 2018

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Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

4 July 2018

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SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory

4 July 2018

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Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.

4 July 2018

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The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

4 July 2018

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

4 July 2018

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The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

4 July 2018

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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

4 July 2018

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CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

4 July 2018

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Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma.

4 July 2018

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Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

4 July 2018

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PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

4 July 2018

1 reference

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PI3 kinase signals BCR-dependent mature B cell survival

4 July 2018

1 reference

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The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

4 July 2018

1 reference

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway

4 July 2018

1 reference

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Bim is a suppressor of Myc-induced mouse B cell leukemia

4 July 2018

1 reference

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

4 July 2018

1 reference

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

4 July 2018

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Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

4 July 2018

1 reference

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Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

4 July 2018

1 reference

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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

4 July 2018

1 reference

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Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5467045

PUMA, a novel proapoptotic gene, is induced by p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5467045

Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5467045

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5467045

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5467045

Role of translocation in the activation and function of protein kinase B

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5467045

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

4 July 2018

1 reference

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Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

R-CHOP with or without bevacizumab in patients with previously untreated diffuse large B-cell lymphoma: final MAIN study outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

IL-4 enhances expression and function of surface IgM in CLL cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2016.333

Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27843137

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2016.333

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27843137%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

27843137

1 reference