(Q37420518)

English

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

scientific article published on 22 September 2009

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scholarly article

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Europe PubMed Central

PMC publication ID

20 August 2017

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

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Paul Dent

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Europe PubMed Central

20 August 2017

PMC publication ID

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Mohamed Rahmani

1

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Europe PubMed Central

PMC publication ID

20 August 2017

Anh Anderson

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Joseph Reza Habibi

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Timothy Ryan Crabtree

4

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Europe PubMed Central

PMC publication ID

20 August 2017

Mandy Mayo

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Hisashi Harada

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Andrea Ferreira-Gonzalez

7

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Europe PubMed Central

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20 August 2017

Steven Grant

9

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Europe PubMed Central

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20 August 2017

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publication date

22 September 2009

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Europe PubMed Central

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20 August 2017

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Europe PubMed Central

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20 August 2017

114

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Europe PubMed Central

PMC publication ID

20 August 2017

20

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

4507-4516

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

1 reference

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1 reference

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1 reference

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

1 reference

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Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)

1 reference

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The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress

1 reference

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ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

1 reference

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Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

1 reference

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1 reference

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NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition

1 reference

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14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells

1 reference

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1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777129

23 August 2017

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

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Sensitive sequencing method for KRAS mutation detection by Pyrosequencing

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777129

23 August 2017

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777129

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777129

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Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777129

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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

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Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

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Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways

1 reference

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Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

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D-21266, a new heterocyclic alkylphospholipid with antitumour activity

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inferred from PubMed ID database lookup

Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19773546

12 December 2020

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19773546

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2008-09-177881

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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